BDBM50101793 CHEMBL3394941

SMILES: Cc1cn(cn1)-c1ccc2C(=O)N(Cc3cnn4ccc(cc34)C(F)(F)F)CCn2c1=O

InChI Key: InChIKey=VMSOTCHPXVSCJY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50101793   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gamma-Secretase Subunit APH-1A/Gamma-Secretase Subunit PEN-2/Gamma-Secretase Subunit Presenilin-1/Gamma-secretase subunit APH-1B/Nicastrin /Presenilin 2 (Homo sapiens (Human))	BDBM50101793 (CHEMBL3394941) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(Cc3cnn4ccc(cc34)C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C21H17F3N6O2/c1-13-10-28(12-25-13)16-2-3-17-19(31)27(6-7-29(17)20(16)32)11-14-9-26-30-5-4-15(8-18(14)30)21(22,23)24/h2-5,8-10,12H,6-7,11H2,1H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	605	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...				Bioorg Med Chem Lett 25: 908-13 (2015) Article DOI: 10.1016/j.bmcl.2014.12.059 BindingDB Entry DOI: 10.7270/Q2QV3P8R
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