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SMILES: Cc1cn(cn1)-c1ccc2C(=O)N(Cc3cccc4ccc(Cl)cc34)CCn2c1=O

InChI Key: InChIKey=MQHHEMMMFJUBNV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50103135   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2


(Homo sapiens (Human))		BDBM50103135
PNG
(CHEMBL3394927)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(Cc3cccc4ccc(Cl)cc34)CCn2c1=O
Show InChI InChI=1S/C23H19ClN4O2/c1-15-12-27(14-25-15)20-7-8-21-22(29)26(9-10-28(21)23(20)30)13-17-4-2-3-16-5-6-18(24)11-19(16)17/h2-8,11-12,14H,9-10,13H2,1H3
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KEGG

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PC sid
UniChem

Similars
Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...

Bioorg Med Chem Lett 25: 908-13 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.059
BindingDB Entry DOI: 10.7270/Q2QV3P8R
More data for this
Ligand-Target Pair