null

SMILES: Clc1cccc(CN2CC[C@H](N(CCN3CCNCC3)Cc3cncn3Cc3ccc(cc3)C#N)C2=O)c1

InChI Key: InChIKey=OAOZPXOXMVMQBZ-NDEPHWFRSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50103346   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50103346 (4-(5-{[[1-(3-Chloro-benzyl)-2-oxo-pyrrolidin-3-yl]...) Show SMILES Clc1cccc(CN2CC[C@H](N(CCN3CCNCC3)Cc3cncn3Cc3ccc(cc3)C#N)C2=O)c1 Show InChI InChI=1S/C29H34ClN7O/c30-26-3-1-2-25(16-26)20-36-11-8-28(29(36)38)35(15-14-34-12-9-32-10-13-34)21-27-18-33-22-37(27)19-24-6-4-23(17-31)5-7-24/h1-7,16,18,22,28,32H,8-15,19-21H2/t28-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of farnesyl transferase using purified recombinant human enzyme				J Med Chem 44: 2933-49 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RNW
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50103346 (4-(5-{[[1-(3-Chloro-benzyl)-2-oxo-pyrrolidin-3-yl]...) Show SMILES Clc1cccc(CN2CC[C@H](N(CCN3CCNCC3)Cc3cncn3Cc3ccc(cc3)C#N)C2=O)c1 Show InChI InChI=1S/C29H34ClN7O/c30-26-3-1-2-25(16-26)20-36-11-8-28(29(36)38)35(15-14-34-12-9-32-10-13-34)21-27-18-33-22-37(27)19-24-6-4-23(17-31)5-7-24/h1-7,16,18,22,28,32H,8-15,19-21H2/t28-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Concentration required to displace 50% of a potent radiolabeled FTI from farnesyl transferase in cultured H-ras-transformed Rat1 cells				J Med Chem 44: 2933-49 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RNW
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta (Homo sapiens (Human))	BDBM50103346 (4-(5-{[[1-(3-Chloro-benzyl)-2-oxo-pyrrolidin-3-yl]...) Show SMILES Clc1cccc(CN2CC[C@H](N(CCN3CCNCC3)Cc3cncn3Cc3ccc(cc3)C#N)C2=O)c1 Show InChI InChI=1S/C29H34ClN7O/c30-26-3-1-2-25(16-26)20-36-11-8-28(29(36)38)35(15-14-34-12-9-32-10-13-34)21-27-18-33-22-37(27)19-24-6-4-23(17-31)5-7-24/h1-7,16,18,22,28,32H,8-15,19-21H2/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration of geranylgeranyl-protein transferase type I				J Med Chem 44: 2933-49 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RNW
					More data for this Ligand-Target Pair