BDBM50103904 CHEMBL3594100

SMILES: COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(-c5cccc(c5)C(F)(F)F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1

InChI Key: InChIKey=PGGOVVVVCUOUOM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50103904   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50103904 (CHEMBL3594100) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(-c5cccc(c5)C(F)(F)F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C37H38F4N6O5/c1-23-34(45(3)36(49)47(23)26-8-5-7-24(19-26)37(39,40)41)35(48)43-25-9-10-31(28(38)20-25)52-30-11-12-42-29-22-33(32(50-4)21-27(29)30)51-18-6-13-46-16-14-44(2)15-17-46/h5,7-12,19-22H,6,13-18H2,1-4H3,(H,43,48)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay				Bioorg Med Chem 23: 4410-22 (2015) BindingDB Entry DOI: 10.7270/Q28G8NG3
					More data for this Ligand-Target Pair