BDBM50104205 5-Chloro-8-[5-((R)-3-dimethylamino-pyrrolidine-1-sulfonyl)-2-propoxy-phenyl]-2-(4-methoxy-benzyl)-2,7-dihydro-2,3,4,7,9-pentaaza-cyclopenta[a]naphthalen-6-one::CHEMBL76827

SMILES: CCCOc1ccc(cc1-c1nc2c3cn(Cc4ccc(OC)cc4)nc3nc(Cl)c2c(=O)[nH]1)S(=O)(=O)N1CC[C@H](C1)N(C)C

InChI Key: InChIKey=LKRDLYGCRSZOTL-HXUWFJFHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50104205   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50104205 (5-Chloro-8-[5-((R)-3-dimethylamino-pyrrolidine-1-s...) Show SMILES CCCOc1ccc(cc1-c1nc2c3cn(Cc4ccc(OC)cc4)nc3nc(Cl)c2c(=O)[nH]1)S(=O)(=O)N1CC[C@H](C1)N(C)C Show InChI InChI=1S/C31H34ClN7O5S/c1-5-14-44-25-11-10-22(45(41,42)39-13-12-20(17-39)37(2)3)15-23(25)29-33-27-24-18-38(16-19-6-8-21(43-4)9-7-19)36-30(24)34-28(32)26(27)31(40)35-29/h6-11,15,18,20H,5,12-14,16-17H2,1-4H3,(H,33,35,40)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of PDE5 from human platelets				Bioorg Med Chem Lett 11: 2461-4 (2001) BindingDB Entry DOI: 10.7270/Q2BK1BM5
					More data for this Ligand-Target Pair