BDBM50104706 CHEMBL111179::N-[5-(4-Chloro-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-2-phenylmethanesulfonylamino-propionamide
SMILES: C[C@H](NS(=O)(=O)Cc1ccccc1)C(=O)NC1=NN=C(CS1)c1ccc(Cl)cc1
InChI Key: InChIKey=GINBTQGVSPUJLE-ZDUSSCGKSA-N
Data: 8 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Matrix metalloproteinase-9 (Homo sapiens (Human)) | BDBM50104706 (CHEMBL111179 | N-[5-(4-Chloro-phenyl)-6H-[1,3,4]th...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Bielefeld Curated by ChEMBL | Assay Description In vitro inhibition of human matrix metalloprotease-9 | J Med Chem 44: 3231-43 (2001) BindingDB Entry DOI: 10.7270/Q2RN3758 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM50104706 (CHEMBL111179 | N-[5-(4-Chloro-phenyl)-6H-[1,3,4]th...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Bielefeld Curated by ChEMBL | Assay Description In vitro inhibitory activity against the catalytic domain of the human matrix metalloprotease-2 | J Med Chem 44: 3231-43 (2001) BindingDB Entry DOI: 10.7270/Q2RN3758 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Collagenase 3 (Homo sapiens (Human)) | BDBM50104706 (CHEMBL111179 | N-[5-(4-Chloro-phenyl)-6H-[1,3,4]th...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Bielefeld Curated by ChEMBL | Assay Description In Vitro inhibitory activity against the catalytic domain of the matrix metalloprotease-13 | J Med Chem 44: 3231-43 (2001) BindingDB Entry DOI: 10.7270/Q2RN3758 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-14 (MMP14) (Homo sapiens (Human)) | BDBM50104706 (CHEMBL111179 | N-[5-(4-Chloro-phenyl)-6H-[1,3,4]th...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Bielefeld Curated by ChEMBL | Assay Description In vitro inhibitory activity against the ectodomain of the human matrix metalloproteinase-14 | J Med Chem 44: 3231-43 (2001) BindingDB Entry DOI: 10.7270/Q2RN3758 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-14 (MMP14) (Homo sapiens (Human)) | BDBM50104706 (CHEMBL111179 | N-[5-(4-Chloro-phenyl)-6H-[1,3,4]th...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Bielefeld Curated by ChEMBL | Assay Description In vitro inhibitory activity against the catalytic domain of human matrix metalloprotease-14 | J Med Chem 44: 3231-43 (2001) BindingDB Entry DOI: 10.7270/Q2RN3758 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil collagenase (Homo sapiens (Human)) | BDBM50104706 (CHEMBL111179 | N-[5-(4-Chloro-phenyl)-6H-[1,3,4]th...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Bielefeld Curated by ChEMBL | Assay Description Inhibitory activity against matrix metalloprotease-8 | J Med Chem 44: 3231-43 (2001) BindingDB Entry DOI: 10.7270/Q2RN3758 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interstitial collagenase (Homo sapiens (Human)) | BDBM50104706 (CHEMBL111179 | N-[5-(4-Chloro-phenyl)-6H-[1,3,4]th...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Bielefeld Curated by ChEMBL | Assay Description In vitro inhibitory activity against the catalytic domain of the human matrix metalloprotease-1 | J Med Chem 44: 3231-43 (2001) BindingDB Entry DOI: 10.7270/Q2RN3758 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-12 (MMP12) (Homo sapiens (Human)) | BDBM50104706 (CHEMBL111179 | N-[5-(4-Chloro-phenyl)-6H-[1,3,4]th...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 480 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Bielefeld Curated by ChEMBL | Assay Description In Vitro inhibitory activity against the catalytic domain of the matrix metalloprotease-12 | J Med Chem 44: 3231-43 (2001) BindingDB Entry DOI: 10.7270/Q2RN3758 | |||||||||||
More data for this Ligand-Target Pair |