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BDBM50105001 4-tert-Butyl-N-{5-(3-methoxy-phenoxy)-6-[2-(thiazol-2-yloxy)-ethoxy]-pyrimidin-4-yl}-benzenesulfonamide::CHEMBL331580

SMILES: COc1cccc(Oc2c(NS(=O)(=O)c3ccc(cc3)C(C)(C)C)ncnc2OCCOc2nccs2)c1

InChI Key: InChIKey=PCSOOCRUFAOYIE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50105001   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Endothelin receptor ET-A


(Sus scrofa)		BDBM50105001
PNG
(4-tert-Butyl-N-{5-(3-methoxy-phenoxy)-6-[2-(thiazo...)
Show SMILES COc1cccc(Oc2c(NS(=O)(=O)c3ccc(cc3)C(C)(C)C)ncnc2OCCOc2nccs2)c1
Show InChI InChI=1S/C26H28N4O6S2/c1-26(2,3)18-8-10-21(11-9-18)38(31,32)30-23-22(36-20-7-5-6-19(16-20)33-4)24(29-17-28-23)34-13-14-35-25-27-12-15-37-25/h5-12,15-17H,13-14H2,1-4H3,(H,28,29,30)
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PC sid
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Similars
PubMed
n/an/a 12n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of [125I]-ET-1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells

J Med Chem 44: 3355-68 (2001)


BindingDB Entry DOI: 10.7270/Q2QN662B
More data for this
Ligand-Target Pair