BDBM50105597 5-tert-Butyl-3-[3-(5-ethyl-[1,3,4]thiadiazol-2-yl)-ureido]-thiophene-2-carboxylic acid methyl ester::CHEMBL328143::methyl 5-tert-butyl-3-(3-(5-ethyl-1,3,4-thiadiazol-2-yl)ureido)thiophene-2-carboxylate

SMILES: CCc1nnc(NC(=O)Nc2cc(sc2C(=O)OC)C(C)(C)C)s1

InChI Key: InChIKey=KVJQMCNBZWMWMW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50105597   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50105597 (5-tert-Butyl-3-[3-(5-ethyl-[1,3,4]thiadiazol-2-yl)...) Show SMILES CCc1nnc(NC(=O)Nc2cc(sc2C(=O)OC)C(C)(C)C)s1 Show InChI InChI=1S/C15H20N4O3S2/c1-6-10-18-19-14(24-10)17-13(21)16-8-7-9(15(2,3)4)23-11(8)12(20)22-5/h7H,6H2,1-5H3,(H2,16,17,19,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory concentration against raf kinase.				Bioorg Med Chem Lett 11: 2775-8 (2001) BindingDB Entry DOI: 10.7270/Q2NS0VD5
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50105597 (5-tert-Butyl-3-[3-(5-ethyl-[1,3,4]thiadiazol-2-yl)...) Show SMILES CCc1nnc(NC(=O)Nc2cc(sc2C(=O)OC)C(C)(C)C)s1 Show InChI InChI=1S/C15H20N4O3S2/c1-6-10-18-19-14(24-10)17-13(21)16-8-7-9(15(2,3)4)23-11(8)12(20)22-5/h7H,6H2,1-5H3,(H2,16,17,19,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of B-Raf1 (unknown origin)				Eur J Med Chem 44: 1240-9 (2009) Article DOI: 10.1016/j.ejmech.2008.09.016 BindingDB Entry DOI: 10.7270/Q28G8KJ5
					More data for this Ligand-Target Pair