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SMILES: Cc1[nH]n(-c2ccc(C)cc2)c(=O)c1N=Nc1c(O)cc(C(O)=O)c2ccccc12

InChI Key: InChIKey=JBHMARNHYOVYDG-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50105958   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50105958
PNG
(3-Hydroxy-4-[N'-(3-methyl-5-oxo-1-p-tolyl-1,5-dihy...)
Show SMILES Cc1[nH]n(-c2ccc(C)cc2)c(=O)c1N=Nc1c(O)cc(C(O)=O)c2ccccc12 |w:15.17|
Show InChI InChI=1S/C22H18N4O4/c1-12-7-9-14(10-8-12)26-21(28)19(13(2)25-26)23-24-20-16-6-4-3-5-15(16)17(22(29)30)11-18(20)27/h3-11,25,27H,1-2H3,(H,29,30)
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Similars
PubMed
n/an/an/an/a 2.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells

J Med Chem 44: 3730-45 (2001)


BindingDB Entry DOI: 10.7270/Q2MP52KF
More data for this
Ligand-Target Pair