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SMILES: Cc1[nH]n(-c2ccccc2Cl)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O

InChI Key: InChIKey=PUVYXNSSBDVBCI-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50105971   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50105971
PNG
(4-{N'-[1-(2-Chloro-phenyl)-3-methyl-5-oxo-1,5-dihy...)
Show SMILES Cc1[nH]n(-c2ccccc2Cl)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O |w:15.17|
Show InChI InChI=1S/C20H15ClN4O5S/c1-11-18(20(27)25(24-11)15-9-5-4-8-14(15)21)22-23-19-13-7-3-2-6-12(13)17(10-16(19)26)31(28,29)30/h2-10,24,26H,1H3,(H,28,29,30)
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Similars
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells

J Med Chem 44: 3730-45 (2001)


BindingDB Entry DOI: 10.7270/Q2MP52KF
More data for this
Ligand-Target Pair