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SMILES: Cc1[nH]n(-c2ccccc2)c(=O)c1N=Nc1c(O)cc(C(O)=O)c2ccccc12

InChI Key: InChIKey=KAUVMRSQXIYVRJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50105980   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50105980
PNG
(3-Hydroxy-4-[N'-(3-methyl-5-oxo-1-phenyl-1,5-dihyd...)
Show SMILES Cc1[nH]n(-c2ccccc2)c(=O)c1N=Nc1c(O)cc(C(O)=O)c2ccccc12 |w:14.16|
Show InChI InChI=1S/C21H16N4O4/c1-12-18(20(27)25(24-12)13-7-3-2-4-8-13)22-23-19-15-10-6-5-9-14(15)16(21(28)29)11-17(19)26/h2-11,24,26H,1H3,(H,28,29)
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Similars
PubMed
n/an/an/an/a 5.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells

J Med Chem 44: 3730-45 (2001)


BindingDB Entry DOI: 10.7270/Q2MP52KF
More data for this
Ligand-Target Pair