BDBM50106240 6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-carboxamidine::CHEMBL339902

SMILES: NC(=N)c1cc2cc([nH]c2cc1Cl)-c1cccc(-c2ccccc2)c1O

InChI Key: InChIKey=FEKRWNWZMOSVBX-UHFFFAOYSA-N

Data: 7 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50106240   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50106240 (6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES NC(=N)c1cc2cc([nH]c2cc1Cl)-c1cccc(-c2ccccc2)c1O Show InChI InChI=1S/C21H16ClN3O/c22-17-11-18-13(9-16(17)21(23)24)10-19(25-18)15-8-4-7-14(20(15)26)12-5-2-1-3-6-12/h1-11,25-26H,(H3,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description The compound was tested for inhibition of human urokinase type plasminogen activator (microPa)				J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR
					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50106240 (6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES NC(=N)c1cc2cc([nH]c2cc1Cl)-c1cccc(-c2ccccc2)c1O Show InChI InChI=1S/C21H16ClN3O/c22-17-11-18-13(9-16(17)21(23)24)10-19(25-18)15-8-4-7-14(20(15)26)12-5-2-1-3-6-12/h1-11,25-26H,(H3,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description The compound was tested for inhibition of human plasmin				J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR
					More data for this Ligand-Target Pair
Trypsin II (Homo sapiens (Human))	BDBM50106240 (6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES NC(=N)c1cc2cc([nH]c2cc1Cl)-c1cccc(-c2ccccc2)c1O Show InChI InChI=1S/C21H16ClN3O/c22-17-11-18-13(9-16(17)21(23)24)10-19(25-18)15-8-4-7-14(20(15)26)12-5-2-1-3-6-12/h1-11,25-26H,(H3,23,24)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description The compound was tested for inhibition of human trypsin				J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR
					More data for this Ligand-Target Pair
Coagulation factor VII (Homo sapiens (Human))	BDBM50106240 (6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES NC(=N)c1cc2cc([nH]c2cc1Cl)-c1cccc(-c2ccccc2)c1O Show InChI InChI=1S/C21H16ClN3O/c22-17-11-18-13(9-16(17)21(23)24)10-19(25-18)15-8-4-7-14(20(15)26)12-5-2-1-3-6-12/h1-11,25-26H,(H3,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description The compound was tested for inhibition of human coagulation factor VII				J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR
					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50106240 (6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES NC(=N)c1cc2cc([nH]c2cc1Cl)-c1cccc(-c2ccccc2)c1O Show InChI InChI=1S/C21H16ClN3O/c22-17-11-18-13(9-16(17)21(23)24)10-19(25-18)15-8-4-7-14(20(15)26)12-5-2-1-3-6-12/h1-11,25-26H,(H3,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	8.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description The compound was tested for inhibition of human tissue plasminogen activator				J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50106240 (6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES NC(=N)c1cc2cc([nH]c2cc1Cl)-c1cccc(-c2ccccc2)c1O Show InChI InChI=1S/C21H16ClN3O/c22-17-11-18-13(9-16(17)21(23)24)10-19(25-18)15-8-4-7-14(20(15)26)12-5-2-1-3-6-12/h1-11,25-26H,(H3,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity against human coagulation factor X				J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50106240 (6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES NC(=N)c1cc2cc([nH]c2cc1Cl)-c1cccc(-c2ccccc2)c1O Show InChI InChI=1S/C21H16ClN3O/c22-17-11-18-13(9-16(17)21(23)24)10-19(25-18)15-8-4-7-14(20(15)26)12-5-2-1-3-6-12/h1-11,25-26H,(H3,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceuticals Inc. Curated by ChEMBL					Assay Description The compound was tested for inhibition of human thrombin				J Med Chem 44: 3856-71 (2001) BindingDB Entry DOI: 10.7270/Q22R3QXR
					More data for this Ligand-Target Pair
Hepsin (Homo sapiens (Human))	BDBM50106240 (6-Chloro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...) Show SMILES NC(=N)c1cc2cc([nH]c2cc1Cl)-c1cccc(-c2ccccc2)c1O Show InChI InChI=1S/C21H16ClN3O/c22-17-11-18-13(9-16(17)21(23)24)10-19(25-18)15-8-4-7-14(20(15)26)12-5-2-1-3-6-12/h1-11,25-26H,(H3,23,24)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Korea University Curated by ChEMBL					Assay Description Inhibition of recombinant human hepsin using Boc-QAR-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay				Eur J Med Chem 118: 208-218 (2016) BindingDB Entry DOI: 10.7270/Q2TX3HB6
					More data for this Ligand-Target Pair