BDBM50106794 (R)-N-(5-(2-(bis(4-(difluoromethoxy)phenyl)methylamino)-1-hydroxyethyl)-2-hydroxyphenyl)methanesulfonamide::BMS-194449::CHEMBL320915::N-[5-((R)-2-{[Bis-(4-difluoromethoxy-phenyl)-methyl]-amino}-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide
SMILES: CS(=O)(=O)Nc1cc(ccc1O)[C@@H](O)CNC(c1ccc(OC(F)F)cc1)c1ccc(OC(F)F)cc1
InChI Key: InChIKey=FUKHGCVTMAEHRG-NRFANRHFSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50106794 ((R)-N-(5-(2-(bis(4-(difluoromethoxy)phenyl)methyla...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Binding affinity against CHO cells transfected with human beta-3 adrenergic receptor in the presence of [125I]iodocyanopindolol | Bioorg Med Chem Lett 11: 3035-9 (2001) BindingDB Entry DOI: 10.7270/Q2MS3T97 | |||||||||||
More data for this Ligand-Target Pair |