BDBM50107346 10-Methoxy-2,2,4-trimethyl-5-propyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL336041

SMILES: CCCC1Oc2cccc(OC)c2-c2ccc3NC(C)(C)C=C(C)c3c12

InChI Key: InChIKey=DWGAKCJFXFNMID-UHFFFAOYSA-N

Data: 2 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50107346   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50107346 (10-Methoxy-2,2,4-trimethyl-5-propyl-2,5-dihydro-1H...) Show SMILES CCCC1Oc2cccc(OC)c2-c2ccc3NC(C)(C)C=C(C)c3c12 |t:22| Show InChI InChI=1S/C23H27NO2/c1-6-8-18-22-15(21-17(25-5)9-7-10-19(21)26-18)11-12-16-20(22)14(2)13-23(3,4)24-16/h7,9-13,18,24H,6,8H2,1-5H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity towards glucocorticoid receptor (GR) by displacing [3H]-Dexamethasone				J Med Chem 44: 4481-91 (2001) BindingDB Entry DOI: 10.7270/Q2CZ36F4
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50107346 (10-Methoxy-2,2,4-trimethyl-5-propyl-2,5-dihydro-1H...) Show SMILES CCCC1Oc2cccc(OC)c2-c2ccc3NC(C)(C)C=C(C)c3c12 |t:22| Show InChI InChI=1S/C23H27NO2/c1-6-8-18-22-15(21-17(25-5)9-7-10-19(21)26-18)11-12-16-20(22)14(2)13-23(3,4)24-16/h7,9-13,18,24H,6,8H2,1-5H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity towards progesterone receptor (PR) by displacing [3H]-progesterone.				J Med Chem 44: 4481-91 (2001) BindingDB Entry DOI: 10.7270/Q2CZ36F4
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50107346 (10-Methoxy-2,2,4-trimethyl-5-propyl-2,5-dihydro-1H...) Show SMILES CCCC1Oc2cccc(OC)c2-c2ccc3NC(C)(C)C=C(C)c3c12 |t:22| Show InChI InChI=1S/C23H27NO2/c1-6-8-18-22-15(21-17(25-5)9-7-10-19(21)26-18)11-12-16-20(22)14(2)13-23(3,4)24-16/h7,9-13,18,24H,6,8H2,1-5H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	75	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description The effective concentration in CV-1 cells for glucocorticoid response element activation (GRE).				J Med Chem 44: 4481-91 (2001) BindingDB Entry DOI: 10.7270/Q2CZ36F4
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50107346 (10-Methoxy-2,2,4-trimethyl-5-propyl-2,5-dihydro-1H...) Show SMILES CCCC1Oc2cccc(OC)c2-c2ccc3NC(C)(C)C=C(C)c3c12 |t:22| Show InChI InChI=1S/C23H27NO2/c1-6-8-18-22-15(21-17(25-5)9-7-10-19(21)26-18)11-12-16-20(22)14(2)13-23(3,4)24-16/h7,9-13,18,24H,6,8H2,1-5H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Effective concentration in HepG2 cells transfected with LUC gene (E-sel-Luc).				J Med Chem 44: 4481-91 (2001) BindingDB Entry DOI: 10.7270/Q2CZ36F4
					More data for this Ligand-Target Pair