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BDBM50107502 CHEMBL150336::N-Biphenyl-4-ylmethyl-2-[2-(4-fluoro-benzylsulfanyl)-5-(1-methyl-1H-pyrazol-4-ylmethyl)-4-oxo-4H-pyrimidin-1-yl]-N-methyl-acetamide

SMILES: CN(Cc1ccc(cc1)-c1ccccc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1

InChI Key: InChIKey=XHFSTTZYHBLQAH-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50107502   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
LDL-associated phospholipase A2


(Homo sapiens (Human))
BDBM50107502
PNG
(CHEMBL150336 | N-Biphenyl-4-ylmethyl-2-[2-(4-fluor...)
Show SMILES CN(Cc1ccc(cc1)-c1ccccc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1
Show InChI InChI=1S/C32H30FN5O2S/c1-36(18-23-8-12-27(13-9-23)26-6-4-3-5-7-26)30(39)21-38-20-28(16-25-17-34-37(2)19-25)31(40)35-32(38)41-22-24-10-14-29(33)15-11-24/h3-15,17,19-20H,16,18,21-22H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 5n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human Lp-PLA2 (Lp-PLA2).


Bioorg Med Chem Lett 12: 51-5 (2001)


BindingDB Entry DOI: 10.7270/Q2862FR5
More data for this
Ligand-Target Pair