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BDBM50107564 CHEMBL352355::N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-2-phenyl-5-p-tolyl-pyrimidin-4-yl}-4-tert-butyl-benzenesulfonamide

SMILES: Cc1ccc(cc1)-c1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCCOc1ncc(Br)cn1)-c1ccccc1

InChI Key: InChIKey=LIVFMEBNWMOQRF-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50107564   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Endothelin receptor ET-A


(Sus scrofa)		BDBM50107564
PNG
(CHEMBL352355 | N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Show SMILES Cc1ccc(cc1)-c1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCCOc1ncc(Br)cn1)-c1ccccc1
Show InChI InChI=1S/C33H32BrN5O4S/c1-22-10-12-23(13-11-22)28-30(39-44(40,41)27-16-14-25(15-17-27)33(2,3)4)37-29(24-8-6-5-7-9-24)38-31(28)42-18-19-43-32-35-20-26(34)21-36-32/h5-17,20-21H,18-19H2,1-4H3,(H,37,38,39)
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PubMed
n/an/a>10n/an/an/an/an/an/a



Tanabe Seiyaku Co. Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.

Bioorg Med Chem Lett 12: 81-4 (2001)


BindingDB Entry DOI: 10.7270/Q2VX0FSC
More data for this
Ligand-Target Pair