BDBM50108058 4'-(2-Amino-3-mercapto-propylamino)-2'-propoxy-biphenyl-3-carboxylic acid 13(FTI-288)::CHEMBL58822

SMILES: CCCOc1cc(NC[C@@H](N)CS)ccc1-c1cccc(c1)C(O)=O

InChI Key: InChIKey=FSXYFJWXKIMVFY-OAHLLOKOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50108058   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50108058 (4'-(2-Amino-3-mercapto-propylamino)-2'-propoxy-bip...) Show SMILES CCCOc1cc(NC[C@@H](N)CS)ccc1-c1cccc(c1)C(O)=O Show InChI InChI=1S/C19H24N2O3S/c1-2-8-24-18-10-16(21-11-15(20)12-25)6-7-17(18)13-4-3-5-14(9-13)19(22)23/h3-7,9-10,15,21,25H,2,8,11-12,20H2,1H3,(H,22,23)/t15-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells				J Med Chem 45: 177-88 (2001) BindingDB Entry DOI: 10.7270/Q22F7MQ7
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50108058 (4'-(2-Amino-3-mercapto-propylamino)-2'-propoxy-bip...) Show SMILES CCCOc1cc(NC[C@@H](N)CS)ccc1-c1cccc(c1)C(O)=O Show InChI InChI=1S/C19H24N2O3S/c1-2-8-24-18-10-16(21-11-15(20)12-25)6-7-17(18)13-4-3-5-14(9-13)19(22)23/h3-7,9-10,15,21,25H,2,8,11-12,20H2,1H3,(H,22,23)/t15-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells				J Med Chem 45: 177-88 (2001) BindingDB Entry DOI: 10.7270/Q22F7MQ7
					More data for this Ligand-Target Pair