BDBM50108071 4'-(3-Mercapto-benzylamino)-[1,1';2',1'']terphenyl-3-carboxylic acid methyl ester 33(FTI-2314)::CHEMBL293110

SMILES: COC(=O)c1cccc(c1)-c1ccc(NCc2cccc(S)c2)cc1-c1ccccc1

InChI Key: InChIKey=BTHZULPQBZZWQC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50108071   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50108071 (4'-(3-Mercapto-benzylamino)-[1,1';2',1'']terphenyl...) Show SMILES COC(=O)c1cccc(c1)-c1ccc(NCc2cccc(S)c2)cc1-c1ccccc1 Show InChI InChI=1S/C27H23NO2S/c1-30-27(29)22-11-6-10-21(16-22)25-14-13-23(17-26(25)20-8-3-2-4-9-20)28-18-19-7-5-12-24(31)15-19/h2-17,28,31H,18H2,1H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells				J Med Chem 45: 177-88 (2001) BindingDB Entry DOI: 10.7270/Q22F7MQ7
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50108071 (4'-(3-Mercapto-benzylamino)-[1,1';2',1'']terphenyl...) Show SMILES COC(=O)c1cccc(c1)-c1ccc(NCc2cccc(S)c2)cc1-c1ccccc1 Show InChI InChI=1S/C27H23NO2S/c1-30-27(29)22-11-6-10-21(16-22)25-14-13-23(17-26(25)20-8-3-2-4-9-20)28-18-19-7-5-12-24(31)15-19/h2-17,28,31H,18H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells				J Med Chem 45: 177-88 (2001) BindingDB Entry DOI: 10.7270/Q22F7MQ7
					More data for this Ligand-Target Pair