BDBM50109021 (R)-8-(Benzylamino-methyl)-3,6,7,8-tetrahydro-1H-chromeno[7,8-d]imidazol-2-one::CHEMBL420986

SMILES: O=c1[nH]c2ccc3CC[C@H](CNCc4ccccc4)Oc3c2[nH]1

InChI Key: InChIKey=NJDDOYGAHXQMEQ-CQSZACIVSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50109021   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50109021 ((R)-8-(Benzylamino-methyl)-3,6,7,8-tetrahydro-1H-c...) Show SMILES O=c1[nH]c2ccc3CC[C@H](CNCc4ccccc4)Oc3c2[nH]1 Show InChI InChI=1S/C18H19N3O2/c22-18-20-15-9-7-13-6-8-14(23-17(13)16(15)21-18)11-19-10-12-4-2-1-3-5-12/h1-5,7,9,14,19H,6,8,10-11H2,(H2,20,21,22)/t14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.0700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Laboratories Curated by ChEMBL					Assay Description Affinity of compound for D2 receptor in rat striatal membrane determined for agonist state (high affinity state, D2 High) [3H]quinpirole as radioliga...				Bioorg Med Chem Lett 12: 271-4 (2002) BindingDB Entry DOI: 10.7270/Q22J6CDZ
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50109021 ((R)-8-(Benzylamino-methyl)-3,6,7,8-tetrahydro-1H-c...) Show SMILES O=c1[nH]c2ccc3CC[C@H](CNCc4ccccc4)Oc3c2[nH]1 Show InChI InChI=1S/C18H19N3O2/c22-18-20-15-9-7-13-6-8-14(23-17(13)16(15)21-18)11-19-10-12-4-2-1-3-5-12/h1-5,7,9,14,19H,6,8,10-11H2,(H2,20,21,22)/t14-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Laboratories Curated by ChEMBL					Assay Description Affinity for the Human Dopamine receptor D3 was determined using membranes from CHO cells labeled with [3H]spiperone				Bioorg Med Chem Lett 12: 271-4 (2002) BindingDB Entry DOI: 10.7270/Q22J6CDZ
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50109021 ((R)-8-(Benzylamino-methyl)-3,6,7,8-tetrahydro-1H-c...) Show SMILES O=c1[nH]c2ccc3CC[C@H](CNCc4ccccc4)Oc3c2[nH]1 Show InChI InChI=1S/C18H19N3O2/c22-18-20-15-9-7-13-6-8-14(23-17(13)16(15)21-18)11-19-10-12-4-2-1-3-5-12/h1-5,7,9,14,19H,6,8,10-11H2,(H2,20,21,22)/t14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Laboratories Curated by ChEMBL					Assay Description Affinity for the Dopamine receptor D2S was determined using membranes from CHO cells labeled with [3H]spiperone				Bioorg Med Chem Lett 12: 271-4 (2002) BindingDB Entry DOI: 10.7270/Q22J6CDZ
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50109021 ((R)-8-(Benzylamino-methyl)-3,6,7,8-tetrahydro-1H-c...) Show SMILES O=c1[nH]c2ccc3CC[C@H](CNCc4ccccc4)Oc3c2[nH]1 Show InChI InChI=1S/C18H19N3O2/c22-18-20-15-9-7-13-6-8-14(23-17(13)16(15)21-18)11-19-10-12-4-2-1-3-5-12/h1-5,7,9,14,19H,6,8,10-11H2,(H2,20,21,22)/t14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	4.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Laboratories Curated by ChEMBL					Assay Description Affinity of compound for Dopamine receptor D2 in rat striatal membrane determined for antagonist state (low affinity state, D2 Low) with [3H]spiperon...				Bioorg Med Chem Lett 12: 271-4 (2002) BindingDB Entry DOI: 10.7270/Q22J6CDZ
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50109021 ((R)-8-(Benzylamino-methyl)-3,6,7,8-tetrahydro-1H-c...) Show SMILES O=c1[nH]c2ccc3CC[C@H](CNCc4ccccc4)Oc3c2[nH]1 Show InChI InChI=1S/C18H19N3O2/c22-18-20-15-9-7-13-6-8-14(23-17(13)16(15)21-18)11-19-10-12-4-2-1-3-5-12/h1-5,7,9,14,19H,6,8,10-11H2,(H2,20,21,22)/t14-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Laboratories Curated by ChEMBL					Assay Description Affinity for the Human Dopamine receptor D4 was determined using membranes from CHO cells labeled with [3H]spiperone				Bioorg Med Chem Lett 12: 271-4 (2002) BindingDB Entry DOI: 10.7270/Q22J6CDZ
					More data for this Ligand-Target Pair