BDBM50109520 CHEMBL3601724

SMILES: CN1CCN(CC1)c1ccc(Nc2ncc3ncn(Cc4cccc(NC(=O)C=C)c4)c3n2)cc1

InChI Key: InChIKey=GVSJEEZLEXZBPC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50109520   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50109520 (CHEMBL3601724) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3ncn(Cc4cccc(NC(=O)C=C)c4)c3n2)cc1 Show InChI InChI=1S/C26H28N8O/c1-3-24(35)29-21-6-4-5-19(15-21)17-34-18-28-23-16-27-26(31-25(23)34)30-20-7-9-22(10-8-20)33-13-11-32(2)12-14-33/h3-10,15-16,18H,1,11-14,17H2,2H3,(H,29,35)(H,27,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	101	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay				J Med Chem 58: 6589-606 (2015) BindingDB Entry DOI: 10.7270/Q2833TSH
					More data for this Ligand-Target Pair