BindingDB logo
myBDB logout

null

SMILES: CC(C)(C)c1cc(n[nH]1)C(=O)Nc1ccc(F)cc1Cl

InChI Key: InChIKey=JIBORROFCSZUPW-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50109736   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Polyunsaturated fatty acid lipoxygenase ALOX15


(Homo sapiens (Human))		BDBM50109736
PNG
(CHEMBL3604149)
Show SMILES CC(C)(C)c1cc(n[nH]1)C(=O)Nc1ccc(F)cc1Cl
Show InChI InChI=1S/C14H15ClFN3O/c1-14(2,3)12-7-11(18-19-12)13(20)17-10-5-4-8(16)6-9(10)15/h4-7H,1-3H3,(H,17,20)(H,18,19)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...

Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair