BDBM50110299 CHEMBL14754::{3-[4-(3-Piperidin-1-yl-propoxy)-phenyl]-propyl}-(1,2,3,4-tetrahydro-acridin-9-yl)-amine; Oxalic acid

SMILES: C(COc1ccc(CCCNc2c3CCCCc3nc3ccccc23)cc1)CN1CCCCC1

InChI Key: InChIKey=RUKMQESGYBPCTL-UHFFFAOYSA-N

Data: 1 KI  1 IC50  3 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50110299   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50110299 (CHEMBL14754 | {3-[4-(3-Piperidin-1-yl-propoxy)-phe...) Show SMILES C(COc1ccc(CCCNc2c3CCCCc3nc3ccccc23)cc1)CN1CCCCC1 Show InChI InChI=1S/C30H39N3O/c1-6-20-33(21-7-1)22-9-23-34-25-17-15-24(16-18-25)10-8-19-31-30-26-11-2-4-13-28(26)32-29-14-5-3-12-27(29)30/h2,4,11,13,15-18H,1,3,5-10,12,14,19-23H2,(H,31,32)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Affinity for displacement of [125I]-iodoproxyfan from human histamine H3 receptors stably expressed in CHO cells				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
HRH3 (GUINEA PIG)	BDBM50110299 (CHEMBL14754 | {3-[4-(3-Piperidin-1-yl-propoxy)-phe...) Show SMILES C(COc1ccc(CCCNc2c3CCCCc3nc3ccccc23)cc1)CN1CCCCC1 Show InChI InChI=1S/C30H39N3O/c1-6-20-33(21-7-1)22-9-23-34-25-17-15-24(16-18-25)10-8-19-31-30-26-11-2-4-13-28(26)32-29-14-5-3-12-27(29)30/h2,4,11,13,15-18H,1,3,5-10,12,14,19-23H2,(H,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	63.1	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Activity at Histamine H3 receptor using functional H3 receptor assay on guinea pig ileum				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50110299 (CHEMBL14754 | {3-[4-(3-Piperidin-1-yl-propoxy)-phe...) Show SMILES C(COc1ccc(CCCNc2c3CCCCc3nc3ccccc23)cc1)CN1CCCCC1 Show InChI InChI=1S/C30H39N3O/c1-6-20-33(21-7-1)22-9-23-34-25-17-15-24(16-18-25)10-8-19-31-30-26-11-2-4-13-28(26)32-29-14-5-3-12-27(29)30/h2,4,11,13,15-18H,1,3,5-10,12,14,19-23H2,(H,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Activity at Histamine H2 receptor using functional H2 receptor assay on guinea pig atrium				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110299 (CHEMBL14754 | {3-[4-(3-Piperidin-1-yl-propoxy)-phe...) Show SMILES C(COc1ccc(CCCNc2c3CCCCc3nc3ccccc23)cc1)CN1CCCCC1 Show InChI InChI=1S/C30H39N3O/c1-6-20-33(21-7-1)22-9-23-34-25-17-15-24(16-18-25)10-8-19-31-30-26-11-2-4-13-28(26)32-29-14-5-3-12-27(29)30/h2,4,11,13,15-18H,1,3,5-10,12,14,19-23H2,(H,31,32)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50110299 (CHEMBL14754 | {3-[4-(3-Piperidin-1-yl-propoxy)-phe...) Show SMILES C(COc1ccc(CCCNc2c3CCCCc3nc3ccccc23)cc1)CN1CCCCC1 Show InChI InChI=1S/C30H39N3O/c1-6-20-33(21-7-1)22-9-23-34-25-17-15-24(16-18-25)10-8-19-31-30-26-11-2-4-13-28(26)32-29-14-5-3-12-27(29)30/h2,4,11,13,15-18H,1,3,5-10,12,14,19-23H2,(H,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair