BDBM50110360 CHEMBL3605452
SMILES: COC[C@@H](C)n1c(C)c(C(=O)NCc2c(C)cc(C)nc2O)c2ccccc12
InChI Key: InChIKey=WKFRRFRFXHKQES-OAHLLOKOSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM50110360 (CHEMBL3605452) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Constellation Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of EZH2 Y641N mutant (unknown origin) using biotinylated nucleosome, H3K27me3 activator and [3H]-SAM incubated for 60 mins by top-count ba... | Bioorg Med Chem Lett 25: 3644-9 (2015) BindingDB Entry DOI: 10.7270/Q2Q24205 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM50110360 (CHEMBL3605452) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 703 | n/a | n/a | n/a | n/a | n/a | n/a |
Constellation Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of EZH2 in human HeLa cells assessed as reduction in H3K27me3 levels incubated for 72 hrs by ELISA method | Bioorg Med Chem Lett 25: 3644-9 (2015) BindingDB Entry DOI: 10.7270/Q2Q24205 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM50110360 (CHEMBL3605452) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Constellation Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of EZH2 (unknown origin) using biotinylated nucleosome, H3K27me3 activator and [3H]-SAM incubated for 60 mins by top-count based method | Bioorg Med Chem Lett 25: 3644-9 (2015) BindingDB Entry DOI: 10.7270/Q2Q24205 | |||||||||||
More data for this Ligand-Target Pair |