Found 13 hits for monomerid = 50110704 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Gamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50110704
(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)Show InChI InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3 | PDB
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| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to GABAA alpha5beta3gamma2 (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-004-0014-x BindingDB Entry DOI: 10.7270/Q2RX9DKR |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50110704
(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)Show InChI InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3 | PDB
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| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha5-beta3-gamma2 subunits |
J Med Chem 45: 1176-9 (2002)
BindingDB Entry DOI: 10.7270/Q26Q1WKG |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50110704
(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)Show InChI InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3 | PDB
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| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
| Assay Description Binding affinity to human GABA A alpha5-beta3-gamma2 receptor,using a [3H]-Ro- 15-1788 radioligand |
J Med Chem 46: 2227-40 (2003)
Article DOI: 10.1021/jm020582q BindingDB Entry DOI: 10.7270/Q2BK1BP2 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-2/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50110704
(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)Show InChI InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3 | PDB
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to GABAA alpha2beta3gamma2 (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-004-0014-x BindingDB Entry DOI: 10.7270/Q2RX9DKR |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-2/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50110704
(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)Show InChI InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3 | PDB
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
| Assay Description Binding affinity to human gamma-amino butyric-acid A receptor alpha2beta3gamma2, using a [3H]-Ro- 15-1788 radioligand |
J Med Chem 46: 2227-40 (2003)
Article DOI: 10.1021/jm020582q BindingDB Entry DOI: 10.7270/Q2BK1BP2 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-2/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50110704
(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)Show InChI InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3 | PDB
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha2-beta3-gamma2 subunits |
J Med Chem 45: 1176-9 (2002)
BindingDB Entry DOI: 10.7270/Q26Q1WKG |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50110704
(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)Show InChI InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3 | PDB
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
| Assay Description Binding affinity to human gamma-aminobutyric-acid A receptor alpha1beta3gamma2, determined using [3H]-Ro- 15-1788 radioligand |
J Med Chem 46: 2227-40 (2003)
Article DOI: 10.1021/jm020582q BindingDB Entry DOI: 10.7270/Q2BK1BP2 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50110704
(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)Show InChI InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3 | PDB
UniProtKB/SwissProt
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| Article PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
| Assay Description Binding affinity to human gamma-amino butyric-acid A receptor alpha3beta3gamma2, using a [3H]-Ro- 15-1788 radioligand |
J Med Chem 46: 2227-40 (2003)
Article DOI: 10.1021/jm020582q BindingDB Entry DOI: 10.7270/Q2BK1BP2 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50110704
(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)Show InChI InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha1-beta3-gamma2 subunits |
J Med Chem 45: 1176-9 (2002)
BindingDB Entry DOI: 10.7270/Q26Q1WKG |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50110704
(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)Show InChI InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3 | PDB
UniProtKB/SwissProt
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to GABA-Aalpha1beta3gamma2 (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-004-0014-x BindingDB Entry DOI: 10.7270/Q2RX9DKR |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50110704
(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)Show InChI InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha3-beta3-gamma2 subunits |
J Med Chem 45: 1176-9 (2002)
BindingDB Entry DOI: 10.7270/Q26Q1WKG |
More data for this Ligand-Target Pair | |
Leucine-rich repeat serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50110704
(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)Show InChI InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3 | PDB
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| 5.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human recombinant LRRK2 G2019S mutant using fluorescein- ERM as substrate after 1 hr by TR-FRET assay |
Bioorg Med Chem Lett 26: 2631-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.021 BindingDB Entry DOI: 10.7270/Q2RV0QKC |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50110704
(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)Show InChI InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3 | PDB
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| n/a | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inverse agonist activity at GABAA alpha5beta3gamma2 in Homo sapiens (human) L(tk-) cells by patch clamp assay |
Citation and Details
Article DOI: 10.1007/s00044-004-0014-x BindingDB Entry DOI: 10.7270/Q2RX9DKR |
More data for this Ligand-Target Pair | |