Found 23 hits for monomerid = 50110788 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University
Curated by ChEMBL
| Assay Description In vitro inhibition of [3H]-citalopram binding to human serotonin transporter expressed in human HEK-293 cells |
J Med Chem 48: 4254-65 (2005)
Article DOI: 10.1021/jm050079o BindingDB Entry DOI: 10.7270/Q20R9NZ1 |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.620 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut für Interdisziplinäre Isotopenforschung
Curated by ChEMBL
| Assay Description Displacement of [3H]paroxetine from SERT in rat brain |
Bioorg Med Chem Lett 17: 4991-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.02.082 BindingDB Entry DOI: 10.7270/Q2B27TZJ |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.730 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut für Interdisziplinäre Isotopenforschung
Curated by ChEMBL
| Assay Description Displacement of [3H]citalopram from human SERT expressed in HEK293 cells |
Bioorg Med Chem Lett 18: 4727-30 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.077 BindingDB Entry DOI: 10.7270/Q2M61K2K |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania
Curated by ChEMBL
| Assay Description In vitro binding affinity of the compound in LLC-PK1 cells by SERT binding assay by using [125I]-IDAM as a radioligand |
J Med Chem 45: 4716-23 (2002)
BindingDB Entry DOI: 10.7270/Q23N22RJ |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
| Assay Description In vitro displacement of [3H]-paroxetine from human serotonin transporter expressed in HEK-293 cells |
J Med Chem 48: 2559-70 (2005)
Article DOI: 10.1021/jm0400808 BindingDB Entry DOI: 10.7270/Q2K9371G |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description Displacement of [3H]citalopram from human cloned SERT expressed in HEK293 cells |
Bioorg Med Chem 18: 236-41 (2010)
Article DOI: 10.1016/j.bmc.2009.10.062 BindingDB Entry DOI: 10.7270/Q2348KFT |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 1.65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description Inhibition of [3H]-paroxetine binding to serotonin transporter (SERT) of rat cortical membrane |
J Med Chem 45: 1253-8 (2002)
BindingDB Entry DOI: 10.7270/Q2TH8M15 |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description Displacement of [3H]paroxetine from SERT |
Bioorg Med Chem Lett 16: 1297-300 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.066 BindingDB Entry DOI: 10.7270/Q2Z037R6 |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description Displacement of [3H]MADAM from SERT in rat brain cortex membrane |
Bioorg Med Chem 16: 9050-5 (2008)
Article DOI: 10.1016/j.bmc.2008.08.002 BindingDB Entry DOI: 10.7270/Q21G0M3J |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description Displacement of [3H]paroxetine from SERT in rat brain cortex membrane |
Bioorg Med Chem 16: 9050-5 (2008)
Article DOI: 10.1016/j.bmc.2008.08.002 BindingDB Entry DOI: 10.7270/Q21G0M3J |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 2.03 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut für Interdisziplinäre Isotopenforschung
Curated by ChEMBL
| Assay Description Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells |
Bioorg Med Chem Lett 18: 4727-30 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.077 BindingDB Entry DOI: 10.7270/Q2M61K2K |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University
Curated by ChEMBL
| Assay Description In vitro inhibition of [3H]-nisoxetine binding to norepinephrine transporter expressed in human kidney cells |
J Med Chem 48: 4254-65 (2005)
Article DOI: 10.1021/jm050079o BindingDB Entry DOI: 10.7270/Q20R9NZ1 |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
| Assay Description In vitro displacement of [3H]-nisoxetine from human norepinephrine transporter expressed in HEK-293 cells |
J Med Chem 48: 2559-70 (2005)
Article DOI: 10.1021/jm0400808 BindingDB Entry DOI: 10.7270/Q2K9371G |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 325 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human cloned NET expressed in HEK293 cells |
Bioorg Med Chem 16: 9050-5 (2008)
Article DOI: 10.1016/j.bmc.2008.08.002 BindingDB Entry DOI: 10.7270/Q21G0M3J |
More data for this Ligand-Target Pair | |
Norepinephrine Monoamine transporters
(Rattus norvegicus) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | Reactome pathway KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 325 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description Inhibition of [3H]-nisoxatine binding to norepinephrine transporter (NET) of rat cortical homogenates |
J Med Chem 45: 1253-8 (2002)
BindingDB Entry DOI: 10.7270/Q2TH8M15 |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 532 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University
Curated by ChEMBL
| Assay Description In vitro inhibition of [3H]-WIN- 35,428 binding to human dopamine transporter expressed in canine kidney cells |
J Med Chem 48: 4254-65 (2005)
Article DOI: 10.1021/jm050079o BindingDB Entry DOI: 10.7270/Q20R9NZ1 |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description Inhibition of [3H]-GBR-12,935 binding to dopamine transporter (DAT) of rat striatal membranes |
J Med Chem 45: 1253-8 (2002)
BindingDB Entry DOI: 10.7270/Q2TH8M15 |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description Displacement of [3H]GBR12935 from human cloned DAT expressed in HEK293 cells |
Bioorg Med Chem 16: 9050-5 (2008)
Article DOI: 10.1016/j.bmc.2008.08.002 BindingDB Entry DOI: 10.7270/Q21G0M3J |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Univ. Tours
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 147-52 (2006)
Article DOI: 10.1124/jpet.105.096792 BindingDB Entry DOI: 10.7270/Q2JW8CFZ |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 4.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut für Interdisziplinäre Isotopenforschung
Curated by ChEMBL
| Assay Description Displacement of [3H]WIN35428 from DAT in rat brain |
Bioorg Med Chem Lett 17: 4991-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.02.082 BindingDB Entry DOI: 10.7270/Q2B27TZJ |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
| Assay Description In vitro displacement of [3H]-GBR-12,935 from human dopamine transporter expressed in HEK-293 cells |
J Med Chem 48: 2559-70 (2005)
Article DOI: 10.1021/jm0400808 BindingDB Entry DOI: 10.7270/Q2K9371G |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description Inhibitory activity against NET |
Bioorg Med Chem Lett 16: 1297-300 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.066 BindingDB Entry DOI: 10.7270/Q2Z037R6 |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50110788
(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)Show InChI InChI=1S/C16H20N2S/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM
Curated by ChEMBL
| Assay Description Inhibitory activity against DAT |
Bioorg Med Chem Lett 16: 1297-300 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.066 BindingDB Entry DOI: 10.7270/Q2Z037R6 |
More data for this Ligand-Target Pair | |