BDBM50111470 CHEMBL1232944
SMILES: C=CC(=O)Nc1ccc2c(Nc3cc[nH]n3)nc(nc2c1)-c1ccccc1
InChI Key: InChIKey=DBXZXNJCPSGVAC-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM50111470 (CHEMBL1232944) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
TU Dortmund University Curated by ChEMBL | Assay Description Inhibition of cSrc T338M mutant (unknown origin) pre-incubated for 30 mins before substrate and ATP addition by HTRF assay | J Med Chem 58: 6844-63 (2015) BindingDB Entry DOI: 10.7270/Q2WM1G59 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM50111470 (CHEMBL1232944) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 211 | n/a | n/a | n/a | n/a | n/a | n/a |
TU Dortmund University Curated by ChEMBL | Assay Description Inhibition of wild type cSrc (251 to 533 residues) (unknown origin) pre-incubated for 30 mins before substrate and ATP addition by HTRF assay | J Med Chem 58: 6844-63 (2015) BindingDB Entry DOI: 10.7270/Q2WM1G59 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50111470 (CHEMBL1232944) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TU Dortmund University Curated by ChEMBL | Assay Description Inhibition of wild type EGFR (unknown origin) expressed in Sf9 cells pre-incubated for 30 mins before substrate and ATP addition by homogeneous time-... | J Med Chem 58: 6844-63 (2015) BindingDB Entry DOI: 10.7270/Q2WM1G59 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM50111470 (CHEMBL1232944) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
TU Dortmund University Curated by ChEMBL | Assay Description Inhibition of cSrc T338M/S345C mutant (unknown origin) pre-incubated for 30 mins before substrate and ATP addition by HTRF assay | J Med Chem 58: 6844-63 (2015) BindingDB Entry DOI: 10.7270/Q2WM1G59 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |