BDBM50114234 1-[4-(4-Amino-benzyl)-phenyl]-3-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-urea::CHEMBL39931

SMILES: Cn1nc(cc1NC(=O)Nc1ccc(Cc2ccc(N)cc2)cc1)C(C)(C)C

InChI Key: InChIKey=MLGCXSRYVCKDMU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50114234   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50114234 (1-[4-(4-Amino-benzyl)-phenyl]-3-(5-tert-butyl-2-me...) Show SMILES Cn1nc(cc1NC(=O)Nc1ccc(Cc2ccc(N)cc2)cc1)C(C)(C)C Show InChI InChI=1S/C22H27N5O/c1-22(2,3)19-14-20(27(4)26-19)25-21(28)24-18-11-7-16(8-12-18)13-15-5-9-17(23)10-6-15/h5-12,14H,13,23H2,1-4H3,(H2,24,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2				Bioorg Med Chem Lett 12: 1559-62 (2002) BindingDB Entry DOI: 10.7270/Q2CV4H28
					More data for this Ligand-Target Pair