BDBM50114248 (4-{4-[3-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-ureido]-benzyl}-phenyl)-carbamic acid tert-butyl ester::CHEMBL38625

SMILES: Cn1nc(cc1NC(=O)Nc1ccc(Cc2ccc(NC(=O)OC(C)(C)C)cc2)cc1)C(C)(C)C

InChI Key: InChIKey=JCWLOOOEFZTTNG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50114248   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50114248 ((4-{4-[3-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-u...) Show SMILES Cn1nc(cc1NC(=O)Nc1ccc(Cc2ccc(NC(=O)OC(C)(C)C)cc2)cc1)C(C)(C)C Show InChI InChI=1S/C27H35N5O3/c1-26(2,3)22-17-23(32(7)31-22)30-24(33)28-20-12-8-18(9-13-20)16-19-10-14-21(15-11-19)29-25(34)35-27(4,5)6/h8-15,17H,16H2,1-7H3,(H,29,34)(H2,28,30,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2				Bioorg Med Chem Lett 12: 1559-62 (2002) BindingDB Entry DOI: 10.7270/Q2CV4H28
					More data for this Ligand-Target Pair