BDBM50114255 1-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-3-[4-(2-pyridin-4-yl-ethyl)-phenyl]-urea::CHEMBL38648

SMILES: Cn1nc(cc1NC(=O)Nc1ccc(CCc2ccncc2)cc1)C(C)(C)C

InChI Key: InChIKey=JCCSWTXRFFYGOF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50114255   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50114255 (1-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-3-[4-(2-...) Show SMILES Cn1nc(cc1NC(=O)Nc1ccc(CCc2ccncc2)cc1)C(C)(C)C Show InChI InChI=1S/C22H27N5O/c1-22(2,3)19-15-20(27(4)26-19)25-21(28)24-18-9-7-16(8-10-18)5-6-17-11-13-23-14-12-17/h7-15H,5-6H2,1-4H3,(H2,24,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2				Bioorg Med Chem Lett 12: 1559-62 (2002) BindingDB Entry DOI: 10.7270/Q2CV4H28
					More data for this Ligand-Target Pair