BindingDB PrimarySearch

BDBM50114418 8-Methoxy-2-trifluoromethyl-quinoline-5-carboxylic acid (3,5-dichloro-pyridin-4-yl)-amide::CHEMBL40200::N-(3,5-dichloropyridin-4-yl)-8-methoxy-2-(trifluoromethyl)quinoline-5-carboxamide::SCH-365351

SMILES: COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2ccc(nc12)C(F)(F)F

InChI Key: InChIKey=HBRLPTMZNRCNBL-UHFFFAOYSA-N

Data: 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50114418
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Phosphodiesterase 11A (PDE11A) (Homo sapiens (Human))	BDBM50114418 (8-Methoxy-2-trifluoromethyl-quinoline-5-carboxylic...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of PDE11				Bioorg Med Chem Lett 17: 5150-4 (2007) Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50114418 (8-Methoxy-2-trifluoromethyl-quinoline-5-carboxylic...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of PDE4B				Bioorg Med Chem Lett 17: 5150-4 (2007) Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50114418 (8-Methoxy-2-trifluoromethyl-quinoline-5-carboxylic...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of PDE10				Bioorg Med Chem Lett 17: 5150-4 (2007) Article DOI: 10.1016/j.bmcl.2007.06.092 BindingDB Entry DOI: 10.7270/Q2862G4H
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50114418 (8-Methoxy-2-trifluoromethyl-quinoline-5-carboxylic...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PDE4 in Homo sapiens (human) U937 cells				Citation and Details Article DOI: 10.1007/s00044-012-0457-4 BindingDB Entry DOI: 10.7270/Q2CR5X7T
TBA					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rattus norvegicus)	BDBM50114418 (8-Methoxy-2-trifluoromethyl-quinoline-5-carboxylic...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Corporation Curated by ChEMBL					Assay Description Inhibition of rolipram binding to PDE4 in rat brain				Bioorg Med Chem Lett 12: 1617-9 (2002) BindingDB Entry DOI: 10.7270/Q289182S
Schering-Plough Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50114418 (8-Methoxy-2-trifluoromethyl-quinoline-5-carboxylic...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Corporation Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 4 from human U937 cells				Bioorg Med Chem Lett 12: 1621-3 (2002) BindingDB Entry DOI: 10.7270/Q24J0HB2
Schering-Plough Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rattus norvegicus)	BDBM50114418 (8-Methoxy-2-trifluoromethyl-quinoline-5-carboxylic...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Corporation Curated by ChEMBL					Assay Description Inhibition of rolipram binding to PDE4 of rat brain				Bioorg Med Chem Lett 12: 1621-3 (2002) BindingDB Entry DOI: 10.7270/Q24J0HB2
Schering-Plough Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50114418 (8-Methoxy-2-trifluoromethyl-quinoline-5-carboxylic...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Corporation Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 4 from human U937 cells				Bioorg Med Chem Lett 12: 1617-9 (2002) BindingDB Entry DOI: 10.7270/Q289182S
Schering-Plough Corporation Curated by ChEMBL					More data for this Ligand-Target Pair