BDBM50114495 2'-Sulfamoyl-biphenyl-4-carboxylic acid [2-(1-amino-isoquinolin-7-yloxy)-5-trifluoromethyl-phenyl]-amide::CHEMBL46938

SMILES: Nc1nccc2ccc(Oc3ccc(cc3NC(=O)c3ccc(cc3)-c3ccccc3S(N)(=O)=O)C(F)(F)F)cc12

InChI Key: InChIKey=FMMFHGVZUPFPTH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50114495   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor X (Homo sapiens (Human))	BDBM50114495 (2'-Sulfamoyl-biphenyl-4-carboxylic acid [2-(1-amin...) Show SMILES Nc1nccc2ccc(Oc3ccc(cc3NC(=O)c3ccc(cc3)-c3ccccc3S(N)(=O)=O)C(F)(F)F)cc12 Show InChI InChI=1S/C29H21F3N4O4S/c30-29(31,32)20-10-12-25(40-21-11-9-18-13-14-35-27(33)23(18)16-21)24(15-20)36-28(37)19-7-5-17(6-8-19)22-3-1-2-4-26(22)41(34,38)39/h1-16H,(H2,33,35)(H,36,37)(H2,34,38,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.81E+3	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Tested in vitro for the inhibitory activity against Coagulation factor Xa				Bioorg Med Chem Lett 12: 1657-61 (2002) BindingDB Entry DOI: 10.7270/Q2R49Q2T
					More data for this Ligand-Target Pair