BDBM50115927 4-[3-(4-Cyano-benzyl)-2-methyl-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-trifluoromethoxy-benzyl ester::CHEMBL293639

SMILES: Cc1ncc(CN2CCN(CC2)C(=O)OCc2ccccc2OC(F)(F)F)n1Cc1ccc(cc1)C#N

InChI Key: InChIKey=NKNMRYCDVOOEKZ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50115927   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50115927 (4-[3-(4-Cyano-benzyl)-2-methyl-3H-imidazol-4-ylmet...) Show SMILES Cc1ncc(CN2CCN(CC2)C(=O)OCc2ccccc2OC(F)(F)F)n1Cc1ccc(cc1)C#N Show InChI InChI=1S/C26H26F3N5O3/c1-19-31-15-23(34(19)16-21-8-6-20(14-30)7-9-21)17-32-10-12-33(13-11-32)25(35)36-18-22-4-2-3-5-24(22)37-26(27,28)29/h2-9,15H,10-13,16-18H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Farnesyl protein transferase radiolabel [1-3H] incorporation				Bioorg Med Chem Lett 12: 2027-30 (2002) BindingDB Entry DOI: 10.7270/Q2TQ60VS
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50115927 (4-[3-(4-Cyano-benzyl)-2-methyl-3H-imidazol-4-ylmet...) Show SMILES Cc1ncc(CN2CCN(CC2)C(=O)OCc2ccccc2OC(F)(F)F)n1Cc1ccc(cc1)C#N Show InChI InChI=1S/C26H26F3N5O3/c1-19-31-15-23(34(19)16-21-8-6-20(14-30)7-9-21)17-32-10-12-33(13-11-32)25(35)36-18-22-4-2-3-5-24(22)37-26(27,28)29/h2-9,15H,10-13,16-18H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [1-3H]-GGPP incorporation into biotinylated K4B-Ras peptide by geranylgeranyl transferase in the presence of 5 mM ATP				Bioorg Med Chem Lett 12: 2027-30 (2002) BindingDB Entry DOI: 10.7270/Q2TQ60VS
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50115927 (4-[3-(4-Cyano-benzyl)-2-methyl-3H-imidazol-4-ylmet...) Show SMILES Cc1ncc(CN2CCN(CC2)C(=O)OCc2ccccc2OC(F)(F)F)n1Cc1ccc(cc1)C#N Show InChI InChI=1S/C26H26F3N5O3/c1-19-31-15-23(34(19)16-21-8-6-20(14-30)7-9-21)17-32-10-12-33(13-11-32)25(35)36-18-22-4-2-3-5-24(22)37-26(27,28)29/h2-9,15H,10-13,16-18H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [1-3H]-GGPP incorporation into biotinylated K4B-Ras peptide by geranylgeranyl transferase in the presence of 5 mM ATP				Bioorg Med Chem Lett 12: 2027-30 (2002) BindingDB Entry DOI: 10.7270/Q2TQ60VS
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50115927 (4-[3-(4-Cyano-benzyl)-2-methyl-3H-imidazol-4-ylmet...) Show SMILES Cc1ncc(CN2CCN(CC2)C(=O)OCc2ccccc2OC(F)(F)F)n1Cc1ccc(cc1)C#N Show InChI InChI=1S/C26H26F3N5O3/c1-19-31-15-23(34(19)16-21-8-6-20(14-30)7-9-21)17-32-10-12-33(13-11-32)25(35)36-18-22-4-2-3-5-24(22)37-26(27,28)29/h2-9,15H,10-13,16-18H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.340	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of radiolabeled farnesyl transferase inhibitor				Bioorg Med Chem Lett 12: 2027-30 (2002) BindingDB Entry DOI: 10.7270/Q2TQ60VS
					More data for this Ligand-Target Pair