null
SMILES: CN(C)CCn1c(=O)\c(=C\c2ccc(O)cc2)s\c1=C1/C(=O)Nc2ccc(F)cc12
InChI Key: InChIKey=IGABLYFTJUACKT-JIBXFAECSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50115980 (CHEMBL3612173) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 1.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The First Affiliated Hospital of Dalian Medical University Curated by ChEMBL | Assay Description Inhibition of P-glycoprotein in human drug-resistant K562/ADR cells assessed as reduction in P-gp mediated rhodamine 123 efflux by spectrofluorometry | Eur J Med Chem 101: 126-32 (2015) BindingDB Entry DOI: 10.7270/Q2PN97FH | |||||||||||
More data for this Ligand-Target Pair |