null

SMILES: Nc1nc(N)c(F)c(-c2nc(c(s2)-c2ccncc2)-c2ccc(F)cc2)c1F

InChI Key: InChIKey=GOLMRNFJEMQOKO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50116028   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Mus musculus (mouse))	BDBM50116028 (3,5-Difluoro-4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl...) Show SMILES Nc1nc(N)c(F)c(-c2nc(c(s2)-c2ccncc2)-c2ccc(F)cc2)c1F Show InChI InChI=1S/C19H12F3N5S/c20-11-3-1-9(2-4-11)15-16(10-5-7-25-8-6-10)28-19(26-15)12-13(21)17(23)27-18(24)14(12)22/h1-8H,(H4,23,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATP				Bioorg Med Chem Lett 12: 2109-12 (2002) BindingDB Entry DOI: 10.7270/Q2610ZNX
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM50116028 (3,5-Difluoro-4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl...) Show SMILES Nc1nc(N)c(F)c(-c2nc(c(s2)-c2ccncc2)-c2ccc(F)cc2)c1F Show InChI InChI=1S/C19H12F3N5S/c20-11-3-1-9(2-4-11)15-16(10-5-7-25-8-6-10)28-19(26-15)12-13(21)17(23)27-18(24)14(12)22/h1-8H,(H4,23,24,27)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description In vivo inhibition of ram seminal vesicle Prostaglandin G/H synthase 1 activity by determining PGE-2 by RIA				Bioorg Med Chem Lett 12: 2109-12 (2002) BindingDB Entry DOI: 10.7270/Q2610ZNX
					More data for this Ligand-Target Pair