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BDBM50116102 CHEMBL302037::[3-(2,4-Dichloro-phenyl)-2,5-dimethyl-2H-pyrazolo[4,3-d]pyrimidin-7-yl]-methyl-amine

SMILES: CNc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12

InChI Key: InChIKey=KQCWVBXUSMSKGJ-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50116102   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50116102
PNG
(CHEMBL302037 | [3-(2,4-Dichloro-phenyl)-2,5-dimeth...)
Show SMILES CNc1nc(C)nc2c(-c3ccc(Cl)cc3Cl)n(C)nc12 |(-3.32,2.46,;-1.98,1.7,;-1.97,.16,;-3.3,-.61,;-3.3,-2.15,;-4.64,-2.92,;-1.97,-2.92,;-.64,-2.15,;.82,-2.63,;1.31,-4.09,;.28,-5.23,;.75,-6.7,;2.26,-7.01,;2.73,-8.47,;3.29,-5.86,;2.8,-4.4,;3.83,-3.25,;1.75,-1.37,;3.29,-1.37,;.82,-.12,;-.64,-.61,)|
Show InChI InChI=1S/C14H13Cl2N5/c1-7-18-11-12(14(17-2)19-7)20-21(3)13(11)9-5-4-8(15)6-10(9)16/h4-6H,1-3H3,(H,17,18,19)
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PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Displacement of [125I]-sauvagine from Corticotropin releasing factor receptor 1 endogenously expressed in IMR-32 human neuroblastoma cells

Bioorg Med Chem Lett 12: 2133-6 (2002)


BindingDB Entry DOI: 10.7270/Q2SQ8ZPK
More data for this
Ligand-Target Pair