BDBM50116252 2-[(3-Carboxy-3-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-propyl)-hydroxy-phosphinoyloxy]-pentanedioic acid::CHEMBL306014

SMILES: CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCP(O)(=O)OC(CCC(O)=O)C(O)=O)C(O)=O

InChI Key: InChIKey=OXLXJCDNQPPJOQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50116252   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate carboxypeptidase II (Rattus norvegicus)	BDBM50116252 (2-[(3-Carboxy-3-{4-[(2,4-diamino-pteridin-6-ylmeth...) Show SMILES CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCP(O)(=O)OC(CCC(O)=O)C(O)=O)C(O)=O Show InChI InChI=1S/C24H29N8O10P/c1-32(11-13-10-27-20-18(28-13)19(25)30-24(26)31-20)14-4-2-12(3-5-14)21(35)29-15(22(36)37)8-9-43(40,41)42-16(23(38)39)6-7-17(33)34/h2-5,10,15-16H,6-9,11H2,1H3,(H,29,35)(H,33,34)(H,36,37)(H,38,39)(H,40,41)(H4,25,26,27,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Guilford Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Compound was evaluated for its ability to inhibit Glutamate carboxypeptidase-II using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate				Bioorg Med Chem Lett 12: 2189-92 (2002) BindingDB Entry DOI: 10.7270/Q21835TN
					More data for this Ligand-Target Pair
Folylpoly-gamma-glutamate synthetase (Homo sapiens (Human))	BDBM50116252 (2-[(3-Carboxy-3-{4-[(2,4-diamino-pteridin-6-ylmeth...) Show SMILES CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCP(O)(=O)OC(CCC(O)=O)C(O)=O)C(O)=O Show InChI InChI=1S/C24H29N8O10P/c1-32(11-13-10-27-20-18(28-13)19(25)30-24(26)31-20)14-4-2-12(3-5-14)21(35)29-15(22(36)37)8-9-43(40,41)42-16(23(38)39)6-7-17(33)34/h2-5,10,15-16H,6-9,11H2,1H3,(H,29,35)(H,33,34)(H,36,37)(H,38,39)(H,40,41)(H4,25,26,27,30,31)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Guilford Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Compound was evaluated for its ability to inhibit Folylpoly-gamma-glutamyl synthetase				Bioorg Med Chem Lett 12: 2189-92 (2002) BindingDB Entry DOI: 10.7270/Q21835TN
					More data for this Ligand-Target Pair