BDBM50116402 2-(2,6-Dichloro-phenylamino)-6,6-dimethyl-1,6-dihydro-imidazo[4,5-h]isoquinoline-7,9-dione::CHEMBL330903

SMILES: CC1(C)C(=O)NC(=O)c2c1ccc1nc(Nc3c(Cl)cccc3Cl)[nH]c21

InChI Key: InChIKey=OHDGUYABCZECFT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50116402   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50116402 (2-(2,6-Dichloro-phenylamino)-6,6-dimethyl-1,6-dihy...) Show SMILES CC1(C)C(=O)NC(=O)c2c1ccc1nc(Nc3c(Cl)cccc3Cl)[nH]c21 Show InChI InChI=1S/C18H14Cl2N4O2/c1-18(2)8-6-7-11-14(12(8)15(25)24-16(18)26)23-17(21-11)22-13-9(19)4-3-5-10(13)20/h3-7H,1-2H3,(H2,21,22,23)(H,24,25,26)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human p56 Lck tyrosine kinase				J Med Chem 45: 3394-405 (2002) BindingDB Entry DOI: 10.7270/Q2CJ8CTW
					More data for this Ligand-Target Pair