BindingDB PrimarySearch

BDBM50116963 2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)-2a,3,4,5-tetrahydrobenzo[cd]indol-2(1H)-one::2a-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]-2a,3,4,5-tetrahydro-1H-benzo[cd]indol-2-one::CHEMBL69257

SMILES: O=C1Nc2cccc3CCCC1(CCCCN1CCC(=CC1)c1ccccc1)c23

InChI Key: InChIKey=JBQOYPLKTTXLSQ-UHFFFAOYSA-N

Data: 22 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50116963
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity towards human 5-hydroxytryptamine 7 receptor				J Med Chem 46: 2795-812 (2003) Article DOI: 10.1021/jm030030n BindingDB Entry DOI: 10.7270/Q2M0465F
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad Complutense Curated by ChEMBL					Assay Description Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand				J Med Chem 46: 5638-50 (2003) Article DOI: 10.1021/jm030841r BindingDB Entry DOI: 10.7270/Q29W0J74
Universidad Complutense Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Meiji Seika Kaisha Ltd. Curated by ChEMBL					Assay Description Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.				J Med Chem 42: 533-5 (1999) Article DOI: 10.1021/jm980519u BindingDB Entry DOI: 10.7270/Q2X63QPV
Meiji Seika Kaisha Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Meiji Seika Kaisha Ltd. Curated by ChEMBL					Assay Description Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand				J Med Chem 45: 2197-206 (2002) Article DOI: 10.1021/jm0104264 BindingDB Entry DOI: 10.7270/Q2S46VRM
Meiji Seika Kaisha Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Catania Curated by ChEMBL					Assay Description Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry				Eur J Med Chem 85: 716-26 (2014) Article DOI: 10.1016/j.ejmech.2014.08.023 BindingDB Entry DOI: 10.7270/Q2DZ09Z8
Universit£ di Catania Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Normandie Univ Curated by ChEMBL					Assay Description Antagonist activity at 5-HT7 receptor (unknown origin)				Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111705
Normandie Univ Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Meiji Seika Kaisha Ltd. Curated by ChEMBL					Assay Description Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells				Bioorg Med Chem Lett 13: 61-4 (2003) BindingDB Entry DOI: 10.7270/Q2959KRF
Meiji Seika Kaisha Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Catania Curated by ChEMBL					Assay Description Binding affinity to 5-HT7 receptor (unknown origin)				J Med Chem 61: 8475-8503 (2018) Article DOI: 10.1021/acs.jmedchem.7b01898 BindingDB Entry DOI: 10.7270/Q2V98BPM
Universit£ di Catania Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Hungarian Academy of Sciences Curated by ChEMBL					Assay Description Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting metho...				Bioorg Med Chem Lett 28: 2418-2421 (2018) Article DOI: 10.1016/j.bmcl.2018.06.019 BindingDB Entry DOI: 10.7270/Q26W9DPS
Hungarian Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NPS Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSD				Bioorg Med Chem Lett 12: 2451-4 (2002) BindingDB Entry DOI: 10.7270/Q25T3JTZ
NPS Pharmaceuticals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Li£ge Curated by ChEMBL					Assay Description Binding affinity to 5HT7 receptor				Bioorg Med Chem Lett 20: 1118-23 (2010) Article DOI: 10.1016/j.bmcl.2009.12.027 BindingDB Entry DOI: 10.7270/Q2TH8MTG
University of Li£ge Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad Complutense Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.				J Med Chem 46: 5638-50 (2003) Article DOI: 10.1021/jm030841r BindingDB Entry DOI: 10.7270/Q29W0J74
Universidad Complutense Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	98	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Meiji Seika Kaisha Ltd. Curated by ChEMBL					Assay Description In vitro binding affinity to 5-hydroxytryptamine 2 receptor of rat cerebral cortex membranes using [3H]ketanserin as the radioligand				J Med Chem 45: 2197-206 (2002) Article DOI: 10.1021/jm0104264 BindingDB Entry DOI: 10.7270/Q2S46VRM
Meiji Seika Kaisha Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Homo sapiens (Human))	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	98	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity towards 5-HT2 receptor				J Med Chem 46: 2795-812 (2003) Article DOI: 10.1021/jm030030n BindingDB Entry DOI: 10.7270/Q2M0465F
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	98	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Meiji Seika Kaisha Ltd. Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 2 receptor by the displacement of [3H]ketanserin in rat cerebral cortex membrane				Bioorg Med Chem Lett 13: 61-4 (2003) BindingDB Entry DOI: 10.7270/Q2959KRF
Meiji Seika Kaisha Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	98	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Meiji Seika Kaisha Ltd. Curated by ChEMBL					Assay Description Compound was evaluated for its ability to displace [3H]ketanserin binding from cloned rat cerebral cortex membranes 5-hydroxytryptamine 2 receptor				J Med Chem 42: 533-5 (1999) Article DOI: 10.1021/jm980519u BindingDB Entry DOI: 10.7270/Q2X63QPV
Meiji Seika Kaisha Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	105	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Meiji Seika Kaisha Ltd. Curated by ChEMBL					Assay Description Compound was evaluated for its ability to displace [3H]spiperone binding from Dopamine receptor D2 in rat striatum.				J Med Chem 42: 533-5 (1999) Article DOI: 10.1021/jm980519u BindingDB Entry DOI: 10.7270/Q2X63QPV
Meiji Seika Kaisha Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	169	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Catania Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry				Eur J Med Chem 85: 716-26 (2014) Article DOI: 10.1016/j.ejmech.2014.08.023 BindingDB Entry DOI: 10.7270/Q2DZ09Z8
Universit£ di Catania Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	169	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Normandie Univ Curated by ChEMBL					Assay Description Antagonist activity at 5-HT1A receptor (unknown origin)				Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111705
Normandie Univ Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Meiji Seika Kaisha Ltd. Curated by ChEMBL					Assay Description Compound was evaluated for its ability to displace [3H]8-OH-DPAT binding from human 5-hydroxytryptamine 1A receptor in mammalian cells				J Med Chem 42: 533-5 (1999) Article DOI: 10.1021/jm980519u BindingDB Entry DOI: 10.7270/Q2X63QPV
Meiji Seika Kaisha Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	525	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Meiji Seika Kaisha Ltd. Curated by ChEMBL					Assay Description Compound was evaluated for its ability to displace [3H]LSD binding from human recombinant 5-hydroxytryptamine 6 receptor				J Med Chem 42: 533-5 (1999) Article DOI: 10.1021/jm980519u BindingDB Entry DOI: 10.7270/Q2X63QPV
Meiji Seika Kaisha Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin 4 (5-HT4) receptor (GUINEA PIG)	BDBM50116963 (2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Meiji Seika Kaisha Ltd. Curated by ChEMBL					Assay Description Compound was evaluated for its ability to displace [3H]GR-113808 binding from 5-hydroxytryptamine 4 receptor in guinea pig striatum.				J Med Chem 42: 533-5 (1999) Article DOI: 10.1021/jm980519u BindingDB Entry DOI: 10.7270/Q2X63QPV
Meiji Seika Kaisha Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair