BDBM50117089 CHEMBL204484::CHEMBL83995::N-[2-(2-Amino-3H-imidazol-4-yl)-ethyl]-3-[4-(3-amino-propoxy)-3,5-dibromo-phenyl]-2-[(E)-hydroxyimino]-propionamide
SMILES: NCCCOc1c(Br)cc(CC(N=O)C(=O)NCCc2cnc(N)[nH]2)cc1Br
InChI Key: InChIKey=IKAZTVWTEIUOHS-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dynein heavy chain (Rattus norvegicus) | BDBM50117089 (CHEMBL204484 | CHEMBL83995 | N-[2-(2-Amino-3H-imid...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by ChEMBL | Assay Description Inhibition of MT-stimulated ATPase activity of rat cytoplasmic dynein heavy chain motor domain | J Med Chem 49: 2063-76 (2006) Article DOI: 10.1021/jm051030l BindingDB Entry DOI: 10.7270/Q2XS5W5T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mycothiol S-conjugate amidase (Mycobacterium tuberculosis) | BDBM50117089 (CHEMBL204484 | CHEMBL83995 | N-[2-(2-Amino-3H-imid...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Inhibition of Mycothiol -S-conjugate amidase (MCA) from mycobacterium tuberculosis | Bioorg Med Chem Lett 12: 2487-90 (2002) BindingDB Entry DOI: 10.7270/Q2XD111C | |||||||||||
More data for this Ligand-Target Pair |