BDBM50117375 4-{6-Methoxy-7-[3-(propane-1-sulfonyl)-propoxy]-quinazolin-4-yl}-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide::CHEMBL124369

SMILES: CCCS(=O)(=O)CCCOc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(OC(C)C)cc3)c2cc1OC

InChI Key: InChIKey=OSLJJXSRAHNNSR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50117375   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50117375 (4-{6-Methoxy-7-[3-(propane-1-sulfonyl)-propoxy]-qu...) Show SMILES CCCS(=O)(=O)CCCOc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(OC(C)C)cc3)c2cc1OC Show InChI InChI=1S/C29H39N5O6S/c1-5-16-41(36,37)17-6-15-39-27-19-25-24(18-26(27)38-4)28(31-20-30-25)33-11-13-34(14-12-33)29(35)32-22-7-9-23(10-8-22)40-21(2)3/h7-10,18-21H,5-6,11-17H2,1-4H3,(H,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasma				J Med Chem 45: 3772-93 (2002) BindingDB Entry DOI: 10.7270/Q2WW7JD9
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50117375 (4-{6-Methoxy-7-[3-(propane-1-sulfonyl)-propoxy]-qu...) Show SMILES CCCS(=O)(=O)CCCOc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(OC(C)C)cc3)c2cc1OC Show InChI InChI=1S/C29H39N5O6S/c1-5-16-41(36,37)17-6-15-39-27-19-25-24(18-26(27)38-4)28(31-20-30-25)33-11-13-34(14-12-33)29(35)32-22-7-9-23(10-8-22)40-21(2)3/h7-10,18-21H,5-6,11-17H2,1-4H3,(H,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	265	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasma				J Med Chem 45: 3772-93 (2002) BindingDB Entry DOI: 10.7270/Q2WW7JD9
					More data for this Ligand-Target Pair