BDBM50117646 CHEMBL3613628
SMILES: CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)C(C)(C)C)cc1
InChI Key: InChIKey=PYHXVRKSQDWXQT-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Transient receptor potential cation channel subfamily V member 4 (TRPV4) (Homo sapiens (Human)) | BDBM50117646 (CHEMBL3613628) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Renovis, Inc. Curated by ChEMBL | Assay Description Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m... | Bioorg Med Chem Lett 25: 4011-5 (2015) BindingDB Entry DOI: 10.7270/Q2PG1THP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 4 (Rattus norvegicus) | BDBM50117646 (CHEMBL3613628) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Renovis, Inc. Curated by ChEMBL | Assay Description Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 min... | Bioorg Med Chem Lett 25: 4011-5 (2015) BindingDB Entry DOI: 10.7270/Q2PG1THP | |||||||||||
More data for this Ligand-Target Pair |