null

SMILES: CCOc1ccc(cc1-c1nc2n(CC(C)(C)C)c(=O)n(C)c(=O)c2[nH]1)S(=O)(=O)N1CCN(C)CC1

InChI Key: InChIKey=WZODXODQWQBUJQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50117728   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50117728 (3-(2,2-Dimethyl-propyl)-8-[2-ethoxy-5-(4-methyl-pi...) Show SMILES CCOc1ccc(cc1-c1nc2n(CC(C)(C)C)c(=O)n(C)c(=O)c2[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C24H34N6O5S/c1-7-35-18-9-8-16(36(33,34)29-12-10-27(5)11-13-29)14-17(18)20-25-19-21(26-20)30(15-24(2,3)4)23(32)28(6)22(19)31/h8-9,14H,7,10-13,15H2,1-6H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	91	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Horsham Research Centre Curated by ChEMBL					Assay Description Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)				Bioorg Med Chem Lett 12: 2587-90 (2002) BindingDB Entry DOI: 10.7270/Q2KW5FC2
					More data for this Ligand-Target Pair
P04972/P11541/P16586/P22571/P23439/Q95142 (Bos taurus-Bos taurus (Bovine))	BDBM50117728 (3-(2,2-Dimethyl-propyl)-8-[2-ethoxy-5-(4-methyl-pi...) Show SMILES CCOc1ccc(cc1-c1nc2n(CC(C)(C)C)c(=O)n(C)c(=O)c2[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C24H34N6O5S/c1-7-35-18-9-8-16(36(33,34)29-12-10-27(5)11-13-29)14-17(18)20-25-19-21(26-20)30(15-24(2,3)4)23(32)28(6)22(19)31/h8-9,14H,7,10-13,15H2,1-6H3,(H,25,26)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Horsham Research Centre Curated by ChEMBL					Assay Description Inhibitory concentration against bovine retina phosphodiesterase 6 activity				Bioorg Med Chem Lett 12: 2587-90 (2002) BindingDB Entry DOI: 10.7270/Q2KW5FC2
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50117728 (3-(2,2-Dimethyl-propyl)-8-[2-ethoxy-5-(4-methyl-pi...) Show SMILES CCOc1ccc(cc1-c1nc2n(CC(C)(C)C)c(=O)n(C)c(=O)c2[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C24H34N6O5S/c1-7-35-18-9-8-16(36(33,34)29-12-10-27(5)11-13-29)14-17(18)20-25-19-21(26-20)30(15-24(2,3)4)23(32)28(6)22(19)31/h8-9,14H,7,10-13,15H2,1-6H3,(H,25,26)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.57E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Horsham Research Centre Curated by ChEMBL					Assay Description Inhibition of human platelet Phosphodiesterase 3				Bioorg Med Chem Lett 12: 2587-90 (2002) BindingDB Entry DOI: 10.7270/Q2KW5FC2
					More data for this Ligand-Target Pair