BDBM50117933 (+)1-[4-(10-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone::CHEMBL340432

SMILES: [O-][n+]1ccc(CC(=O)N2CCC(CC2)[C@H]2c3ncccc3CCc3cc(Cl)cc(Br)c23)cc1

InChI Key: InChIKey=PPXJVZJWVHFFJW-RUZDIDTESA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50117933   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50117933 ((+)1-[4-(10-Bromo-8-chloro-6,11-dihydro-5H-benzo[5...) Show SMILES [O-][n+]1ccc(CC(=O)N2CCC(CC2)[C@H]2c3ncccc3CCc3cc(Cl)cc(Br)c23)cc1 Show InChI InChI=1S/C26H25BrClN3O2/c27-22-16-21(28)15-20-4-3-19-2-1-9-29-26(19)25(24(20)22)18-7-10-30(11-8-18)23(32)14-17-5-12-31(33)13-6-17/h1-2,5-6,9,12-13,15-16,18,25H,3-4,7-8,10-11,14H2/t25-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of Protein farnesyltransferase in Cos-1 monkey kidney cells expressing H-Ras-val				J Med Chem 45: 3854-64 (2002) BindingDB Entry DOI: 10.7270/Q2TD9WPB
					More data for this Ligand-Target Pair