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BDBM50117934 (+ )1-[4-(4-chloro-1,3-dimethyl-3,6,7,12-tetrahydropyrido[2',3':4,5]cyclohepta[e]indol-12-yl)hexahydro-1-pyridinyl]-2-(1-hydroxy-4-pyridiniumyl)-1-ethanone::CHEMBL125344

SMILES: Cc1cn(C)c2c(Cl)cc3CCc4cccnc4C(C4CCN(CC4)C(=O)Cc4cc[n+]([O-])cc4)c3c12

InChI Key: InChIKey=IMDFKXWJJPQADE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50117934   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))		BDBM50117934
PNG
((+ )1-[4-(4-chloro-1,3-dimethyl-3,6,7,12-tetrahydr...)
Show SMILES Cc1cn(C)c2c(Cl)cc3CCc4cccnc4C(C4CCN(CC4)C(=O)Cc4cc[n+]([O-])cc4)c3c12
Show InChI InChI=1S/C30H31ClN4O2/c1-19-18-33(2)30-24(31)17-23-6-5-22-4-3-11-32-29(22)28(27(23)26(19)30)21-9-12-34(13-10-21)25(36)16-20-7-14-35(37)15-8-20/h3-4,7-8,11,14-15,17-18,21,28H,5-6,9-10,12-13,16H2,1-2H3
PDB

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UniProtKB/TrEMBL

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PC cid
PC sid
UniChem

Similars
PubMed
n/an/a>190n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Protein farnesyltransferase in Cos-1 monkey kidney cells expressing H-Ras-val

J Med Chem 45: 3854-64 (2002)


BindingDB Entry DOI: 10.7270/Q2TD9WPB
More data for this
Ligand-Target Pair