BDBM50118293 7-(4-Chloro-phenyl)-8,9-dihydro-7H-7a,10-diaza-pentaleno[1,2-a]naphthalen-7-ol::CHEMBL133646

SMILES: OC1(N2CCN=C2c2c1ccc1ccccc21)c1ccc(Cl)cc1

InChI Key: InChIKey=GYTGCOARTYXPAX-UHFFFAOYSA-N

Data: 3 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50118293   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM50118293 (7-(4-Chloro-phenyl)-8,9-dihydro-7H-7a,10-diaza-pen...) Show SMILES OC1(N2CCN=C2c2c1ccc1ccccc21)c1ccc(Cl)cc1 |c:5| Show InChI InChI=1S/C20H15ClN2O/c21-15-8-6-14(7-9-15)20(24)17-10-5-13-3-1-2-4-16(13)18(17)19-22-11-12-23(19)20/h1-10,24H,11-12H2	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	27.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Drew University Curated by ChEMBL					Assay Description Inhibition of [125I]- RTI -55 binding at the Dopamine transporter sites on HEK-hDAT cells				J Med Chem 45: 4110-8 (2002) BindingDB Entry DOI: 10.7270/Q25Q4VF3
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50118293 (7-(4-Chloro-phenyl)-8,9-dihydro-7H-7a,10-diaza-pen...) Show SMILES OC1(N2CCN=C2c2c1ccc1ccccc21)c1ccc(Cl)cc1 |c:5| Show InChI InChI=1S/C20H15ClN2O/c21-15-8-6-14(7-9-15)20(24)17-10-5-13-3-1-2-4-16(13)18(17)19-22-11-12-23(19)20/h1-10,24H,11-12H2	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	33.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Drew University Curated by ChEMBL					Assay Description Inhibition of [125I]- RTI -55 binding at the Norepinephrin transpoter sites on HEK-hNET cells				J Med Chem 45: 4110-8 (2002) BindingDB Entry DOI: 10.7270/Q25Q4VF3
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50118293 (7-(4-Chloro-phenyl)-8,9-dihydro-7H-7a,10-diaza-pen...) Show SMILES OC1(N2CCN=C2c2c1ccc1ccccc21)c1ccc(Cl)cc1 |c:5| Show InChI InChI=1S/C20H15ClN2O/c21-15-8-6-14(7-9-15)20(24)17-10-5-13-3-1-2-4-16(13)18(17)19-22-11-12-23(19)20/h1-10,24H,11-12H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	224	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Drew University Curated by ChEMBL					Assay Description Inhibition of [125I]- RTI -55 binding at the Serotonin transporter sites on HEK-hSERT cells				J Med Chem 45: 4110-8 (2002) BindingDB Entry DOI: 10.7270/Q25Q4VF3
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50118293 (7-(4-Chloro-phenyl)-8,9-dihydro-7H-7a,10-diaza-pen...) Show SMILES OC1(N2CCN=C2c2c1ccc1ccccc21)c1ccc(Cl)cc1 |c:5| Show InChI InChI=1S/C20H15ClN2O/c21-15-8-6-14(7-9-15)20(24)17-10-5-13-3-1-2-4-16(13)18(17)19-22-11-12-23(19)20/h1-10,24H,11-12H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program/NIH Curated by ChEMBL					Assay Description Ability to displace [3H]-WIN-35,428 from dopamine transporter in rat caudate putamen tissue				J Med Chem 45: 4119-27 (2002) BindingDB Entry DOI: 10.7270/Q21Z43R6
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM50118293 (7-(4-Chloro-phenyl)-8,9-dihydro-7H-7a,10-diaza-pen...) Show SMILES OC1(N2CCN=C2c2c1ccc1ccccc21)c1ccc(Cl)cc1 |c:5| Show InChI InChI=1S/C20H15ClN2O/c21-15-8-6-14(7-9-15)20(24)17-10-5-13-3-1-2-4-16(13)18(17)19-22-11-12-23(19)20/h1-10,24H,11-12H2	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	10.6	n/a	n/a	n/a	n/a	n/a	n/a
Drew University Curated by ChEMBL					Assay Description Ability to displace [3H]- WIN 35,428 from dopamine transporter on guinea pig striatal membrane.				J Med Chem 45: 4110-8 (2002) BindingDB Entry DOI: 10.7270/Q25Q4VF3
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50118293 (7-(4-Chloro-phenyl)-8,9-dihydro-7H-7a,10-diaza-pen...) Show SMILES OC1(N2CCN=C2c2c1ccc1ccccc21)c1ccc(Cl)cc1 |c:5| Show InChI InChI=1S/C20H15ClN2O/c21-15-8-6-14(7-9-15)20(24)17-10-5-13-3-1-2-4-16(13)18(17)19-22-11-12-23(19)20/h1-10,24H,11-12H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	16.0	n/a	n/a	n/a	n/a	n/a	n/a
Drew University Curated by ChEMBL					Assay Description Ability to displace [3H]- WIN 35,428 from dopamine transporter on rat striatal membrane.				J Med Chem 45: 4110-8 (2002) BindingDB Entry DOI: 10.7270/Q25Q4VF3
					More data for this Ligand-Target Pair