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BDBM50119359 2-{4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(3,5-dimethyl-1-oxy-pyridin-4-yl)-ethyl]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol::CHEMBL318108

SMILES: Cc1c[n+]([O-])cc(C)c1CC(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccc(OC(F)F)c(OC(F)F)c1

InChI Key: InChIKey=TXQHCNQOCZKODH-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50119359   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))		BDBM50119359
PNG
(2-{4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(3,5-di...)
Show SMILES Cc1c[n+]([O-])cc(C)c1CC(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccc(OC(F)F)c(OC(F)F)c1
Show InChI InChI=1S/C26H21F10NO4/c1-13-11-37(39)12-14(2)18(13)10-19(16-5-8-20(40-22(27)28)21(9-16)41-23(29)30)15-3-6-17(7-4-15)24(38,25(31,32)33)26(34,35)36/h3-9,11-12,19,22-23,38H,10H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 57n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human Phosphodiesterase 4A isoform using construct representing the common region of spliced variants expressed as GST-fusion proteins ...

Bioorg Med Chem Lett 12: 3009-13 (2002)


BindingDB Entry DOI: 10.7270/Q2V125B1
More data for this
Ligand-Target Pair