BDBM50119372 (R)-N-((R)-1-(4-((1H-tetrazol-5-yl)methyl)-4-cyclohexylpiperidin-1-yl)-3-(4-chlorophenyl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide::1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(1H-tetrazol-5-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide::CHEMBL143131

SMILES: Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(Cc3nnn[nH]3)(CC2)C2CCCCC2)cc1

InChI Key: InChIKey=MOSMZJCDBAMZFP-VSGBNLITSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50119372   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50119372 ((R)-N-((R)-1-(4-((1H-tetrazol-5-yl)methyl)-4-cyclo...) Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(Cc3nnn[nH]3)(CC2)C2CCCCC2)cc1 Show InChI InChI=1S/C32H40ClN7O2/c33-26-12-10-22(11-13-26)18-28(35-30(41)27-19-23-6-4-5-7-24(23)21-34-27)31(42)40-16-14-32(15-17-40,20-29-36-38-39-37-29)25-8-2-1-3-9-25/h4-7,10-13,25,27-28,34H,1-3,8-9,14-21H2,(H,35,41)(H,36,37,38,39)/t27-,28-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	771	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Evaluated for Functional Activity at Melanocortin-4 receptor as effective concentration at 50% maximum CMP accumulation				J Med Chem 45: 4589-93 (2002) BindingDB Entry DOI: 10.7270/Q2GT5MH9
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50119372 ((R)-N-((R)-1-(4-((1H-tetrazol-5-yl)methyl)-4-cyclo...) Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(Cc3nnn[nH]3)(CC2)C2CCCCC2)cc1 Show InChI InChI=1S/C32H40ClN7O2/c33-26-12-10-22(11-13-26)18-28(35-30(41)27-19-23-6-4-5-7-24(23)21-34-27)31(42)40-16-14-32(15-17-40,20-29-36-38-39-37-29)25-8-2-1-3-9-25/h4-7,10-13,25,27-28,34H,1-3,8-9,14-21H2,(H,35,41)(H,36,37,38,39)/t27-,28-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	238	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP production				J Med Chem 47: 6821-30 (2004) Article DOI: 10.1021/jm049278i BindingDB Entry DOI: 10.7270/Q2610ZSQ
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50119372 ((R)-N-((R)-1-(4-((1H-tetrazol-5-yl)methyl)-4-cyclo...) Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(Cc3nnn[nH]3)(CC2)C2CCCCC2)cc1 Show InChI InChI=1S/C32H40ClN7O2/c33-26-12-10-22(11-13-26)18-28(35-30(41)27-19-23-6-4-5-7-24(23)21-34-27)31(42)40-16-14-32(15-17-40,20-29-36-38-39-37-29)25-8-2-1-3-9-25/h4-7,10-13,25,27-28,34H,1-3,8-9,14-21H2,(H,35,41)(H,36,37,38,39)/t27-,28-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	238	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Evaluated for Functional Activity at Melanocortin-4 receptor as effective concentration at 50% maximum CMP accumulation				J Med Chem 45: 4589-93 (2002) BindingDB Entry DOI: 10.7270/Q2GT5MH9
					More data for this Ligand-Target Pair