BDBM50119457 CHEMBL3613878

SMILES: Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl

InChI Key: InChIKey=HMVJSLZLZZJKHU-UHFFFAOYSA-N

Data: 5 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50119457   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50119457 (CHEMBL3613878) Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl Show InChI InChI=1S/C21H21Cl2N7/c22-19-2-1-3-20(21(19)23)28-12-10-27(11-13-28)8-5-16-15-30(26-25-16)18-6-9-29-17(14-18)4-7-24-29/h1-4,6-7,9,14-15H,5,8,10-13H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cell membranes by radioligand competition binding assay				Bioorg Med Chem 23: 6195-209 (2015) BindingDB Entry DOI: 10.7270/Q2WW7KGM
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50119457 (CHEMBL3613878) Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl Show InChI InChI=1S/C21H21Cl2N7/c22-19-2-1-3-20(21(19)23)28-12-10-27(11-13-28)8-5-16-15-30(26-25-16)18-6-9-29-17(14-18)4-7-24-29/h1-4,6-7,9,14-15H,5,8,10-13H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay				Bioorg Med Chem 23: 6195-209 (2015) BindingDB Entry DOI: 10.7270/Q2WW7KGM
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50119457 (CHEMBL3613878) Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl Show InChI InChI=1S/C21H21Cl2N7/c22-19-2-1-3-20(21(19)23)28-12-10-27(11-13-28)8-5-16-15-30(26-25-16)18-6-9-29-17(14-18)4-7-24-29/h1-4,6-7,9,14-15H,5,8,10-13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from human dopamine D2S receptor expressed in CHO cell membranes by radioligand competition binding assay				Bioorg Med Chem 23: 6195-209 (2015) BindingDB Entry DOI: 10.7270/Q2WW7KGM
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50119457 (CHEMBL3613878) Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl Show InChI InChI=1S/C21H21Cl2N7/c22-19-2-1-3-20(21(19)23)28-12-10-27(11-13-28)8-5-16-15-30(26-25-16)18-6-9-29-17(14-18)4-7-24-29/h1-4,6-7,9,14-15H,5,8,10-13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay				Bioorg Med Chem 23: 6195-209 (2015) BindingDB Entry DOI: 10.7270/Q2WW7KGM
					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50119457 (CHEMBL3613878) Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl Show InChI InChI=1S/C21H21Cl2N7/c22-19-2-1-3-20(21(19)23)28-12-10-27(11-13-28)8-5-16-15-30(26-25-16)18-6-9-29-17(14-18)4-7-24-29/h1-4,6-7,9,14-15H,5,8,10-13H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay				Bioorg Med Chem 23: 6195-209 (2015) BindingDB Entry DOI: 10.7270/Q2WW7KGM
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50119457 (CHEMBL3613878) Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl Show InChI InChI=1S/C21H21Cl2N7/c22-19-2-1-3-20(21(19)23)28-12-10-27(11-13-28)8-5-16-15-30(26-25-16)18-6-9-29-17(14-18)4-7-24-29/h1-4,6-7,9,14-15H,5,8,10-13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphai2 by [35S]GTPgammaS...				Bioorg Med Chem 23: 6195-209 (2015) BindingDB Entry DOI: 10.7270/Q2WW7KGM
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50119457 (CHEMBL3613878) Show SMILES Clc1cccc(N2CCN(CCc3cn(nn3)-c3ccn4nccc4c3)CC2)c1Cl Show InChI InChI=1S/C21H21Cl2N7/c22-19-2-1-3-20(21(19)23)28-12-10-27(11-13-28)8-5-16-15-30(26-25-16)18-6-9-29-17(14-18)4-7-24-29/h1-4,6-7,9,14-15H,5,8,10-13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	479	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphao1 by [35S]GTPgammaS...				Bioorg Med Chem 23: 6195-209 (2015) BindingDB Entry DOI: 10.7270/Q2WW7KGM
					More data for this Ligand-Target Pair