Found 3 hits for monomerid = 50119610 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50119610
(CHEMBL3618234)Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccc3ncccc3c2)nc2ccccn12 Show InChI InChI=1S/C20H16N8/c1-12-23-18(27-20(21)24-12)17-19(26-16-6-2-3-10-28(16)17)25-14-7-8-15-13(11-14)5-4-9-22-15/h2-11,25H,1H3,(H2,21,23,24,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 529 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) by alpha screen assay |
Bioorg Med Chem Lett 25: 4136-42 (2015)
BindingDB Entry DOI: 10.7270/Q2R49SKC |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50119610
(CHEMBL3618234)Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccc3ncccc3c2)nc2ccccn12 Show InChI InChI=1S/C20H16N8/c1-12-23-18(27-20(21)24-12)17-19(26-16-6-2-3-10-28(16)17)25-14-7-8-15-13(11-14)5-4-9-22-15/h2-11,25H,1H3,(H2,21,23,24,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >780 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in AKT Ser473 phosphorylation incubated for 2 hrs followed by compound wahout by a... |
Bioorg Med Chem Lett 25: 4136-42 (2015)
BindingDB Entry DOI: 10.7270/Q2R49SKC |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50119610
(CHEMBL3618234)Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccc3ncccc3c2)nc2ccccn12 Show InChI InChI=1S/C20H16N8/c1-12-23-18(27-20(21)24-12)17-19(26-16-6-2-3-10-28(16)17)25-14-7-8-15-13(11-14)5-4-9-22-15/h2-11,25H,1H3,(H2,21,23,24,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 277 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assay |
Bioorg Med Chem Lett 25: 4136-42 (2015)
BindingDB Entry DOI: 10.7270/Q2R49SKC |
More data for this
Ligand-Target Pair | |
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