BDBM50119746 2-{[1-((S)-3-Cyclohexyl-2-mercapto-propionylamino)-cyclopentanecarbonyl]-amino}-3-(6-thiophen-3-yl-pyridin-3-yl)-propionic acid::CHEMBL319463
SMILES: OC(=O)C(Cc1ccc(nc1)-c1ccsc1)NC(=O)C1(CCCC1)NC(=O)[C@@H](S)CC1CCCCC1
InChI Key: InChIKey=SRCXNJMRCQLQHK-WCSIJFPASA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Endothelin-converting enzyme 1 (Homo sapiens (Human)) | BDBM50119746 (2-{[1-((S)-3-Cyclohexyl-2-mercapto-propionylamino)...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of Homo sapiens (human) endothelin converting enzyme-1 | Citation and Details Article DOI: 10.1007/s00044-012-0433-z BindingDB Entry DOI: 10.7270/Q2S185DK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-converting enzyme 1 (ECE1) (Homo sapiens (Human)) | BDBM50119746 (2-{[1-((S)-3-Cyclohexyl-2-mercapto-propionylamino)...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Biomedical Research Curated by ChEMBL | Assay Description In vitro inhibition of Endothelin-converting enzyme 1. | Bioorg Med Chem Lett 12: 3059-62 (2002) BindingDB Entry DOI: 10.7270/Q26D5SCZ | |||||||||||
More data for this Ligand-Target Pair |